Scientific Director Oncology – ETCT Innovation

Role Summary

Scientific Director for Innovation in the Extracellular Targeted Cancer Therapeutics (ETCT) Biology Unit within the Oncology Research Unit, leading outwardly facing technology and business development initiatives to accelerate the build of a targeted biologics portfolio in Oncology. Responsible for guiding cross-functional initiatives to develop the next generation of antibody–drug conjugates (ADCs), interfacing with internal and external partners to accelerate asset development, and consulting with the business development team on identification and assessment of cutting-edge technologies and potential collaborations. Prior experience leading matrix teams with oversight of critical path chemistry and biology in preclinical ADC development is required.

Responsibilities

• Guide the maturation and de-risking of novel therapeutic concepts, specifically antibody drug conjugates (ADCs), through rigorous mechanistic testing in partnership with internal and external business partners.
• Talent scout new technology investments and help build proposals for GSK’s senior leadership for investment.
• Co-lead a team that can collaborate with internal platform groups to deliver success on externally partnered programs and/or technologies.
• Identify new areas for investment at the preclinical research phase, and assist scientific due diligence review of in-licensing opportunities with the business development organization.
• Prioritize innovation projects and allocate resources effectively to drive successful outcomes.
• Collaborate with business development teams to establish strategic partnerships and alliances with external organizations, including startups, research institutions, and pharmaceutical companies.

Qualifications

• PhD in Cancer Biology, Pharmacology, Cellular Biology, or related life science fields with 5+ years post-doctoral training.
• Experience leading cross-functional drug discovery project teams oversighting critical path chemistry and biology to develop novel therapeutic platforms for biologics targets.
• Direct experience developing ADC and novel chemistry.
• Experience developing and implementing scientific strategies in Oncology or related disciplines with 12 to 24-month planning horizons.
• Experience in progressing ADC from concept to candidate selection and supporting critical path mechanistic biology and/or in vivo translational studies.

Skills

• Strong ability to lead matrix teams and collaborate with internal and external partners.
• Strategic thinking with a track record of identifying and evaluating innovative technologies and opportunities.
• Excellent communication, interpersonal, and organizational skills.

Education

• PhD in a life science field such as Cancer Biology, Pharmacology, or Cellular Biology.

Additional Requirements

• On-site office-based presence 2 to 3 days a week in US locations: Upper Providence, PA; Waltham, MA; or other specified sites.