Scientific Associate Director - Safety Pharmacology

Role: Scientific Associate Director leading safety pharmacology activities within Amgen's Translational Safety & Risk Sciences department, focusing on nonclinical safety evaluation for biopharma candidates. Responsibilities include managing in vitro cardiac safety and electrophysiology labs (ion channels, hiPSC-derived cardiomyocytes, isolated heart assays), overseeing GLP-compliant safety studies, supervising staff, and ensuring data quality and compliance. The role provides SME input on safety risk assessments, study design, and regulatory strategies across modalities (small molecules, biologics, emerging therapeutics), supporting candidate selection and clinical translation. It involves external collaboration with academic and industry partners, promoting mechanistic safety understanding and human-relevant in vitro models, and contributing to scientific publications and forums. Requirements: PhD in Pharmacology, Neuroscience, Physiology, or related, with 4+ years relevant experience; or Master's with 7+ years; or Bachelor's with 9+ years. Preferred qualifications include broad safety pharmacology expertise across cardiovascular, respiratory, and CNS domains, experience with ion channel assays (hERG, Nav1.5, Cav1.2), CRO management, and safety pharmacology SME roles. The role reports to the Senior Director of Safety Pharmacology Sciences, involves laboratory leadership, and requires strong cross-functional communication. It is based in a hybrid or on-site setting with no specific travel expectations listed.