Research Scientist II – Analytical Genomics Laboratory
Novartis
August 19, 2026
On-site
Cambridge, MA
Clinical Research and Development
Key Responsibilities
- Perform experiments using established single-cell and spatial profiling workflows.
- Execute sample preparation, library construction, and sequencing-related protocols per SOPs and study plans.
- Provide input on sample requirements, workflow feasibility, timing, and run setup (under guidance).
- Support troubleshooting and implement approved protocol adjustments; escalate technical issues as appropriate.
- Ensure accurate documentation and reproducibility.
- Operate and maintain relevant instruments (routine care and basic troubleshooting).
- Support training of other staff on instrument use and protocol adherence.
- Perform initial data processing for spatial and single-cell genomics datasets using appropriate bioinformatics tools.
- Collaborate with data scientists; contribute to reports and internal presentations.
- Work with local and remote cross-functional teams; communicate experimental status and technical observations.
- Document work accurately; monitor QC measures to ensure data integrity and compliance with lab standards.
- Stay current with advances in single-cell/spatial genomics and help integrate best practices into lab workflows.
Essential Requirements
- MS (or BS + 2 years experience) in Molecular Biology, Genomics, Biochemistry, or related field (or equivalent experience).
- 1–2 years hands-on experience with spatial transcriptomics and/or single-cell sequencing.
- Knowledge of molecular biology techniques including PCR, qRT-PCR, enzymatic reactions, DNA/RNA purification and manipulation.
- Experience troubleshooting and optimizing protocols (with guidance) for complex genomics assays.
- Knowledge of NGS library preparation and sequencing workflows.
Desirable Requirements
- Experience with tissue processing, imaging, IHC, and microscopy.
Application Instructions
- Submit a CV and cover letter summarizing relevant experience with single-cell and spatial omics protocols and instrumentation.
- Perform experiments using established single-cell and spatial profiling workflows.
- Execute sample preparation, library construction, and sequencing-related protocols per SOPs and study plans.
- Provide input on sample requirements, workflow feasibility, timing, and run setup (under guidance).
- Support troubleshooting and implement approved protocol adjustments; escalate technical issues as appropriate.
- Ensure accurate documentation and reproducibility.
- Operate and maintain relevant instruments (routine care and basic troubleshooting).
- Support training of other staff on instrument use and protocol adherence.
- Perform initial data processing for spatial and single-cell genomics datasets using appropriate bioinformatics tools.
- Collaborate with data scientists; contribute to reports and internal presentations.
- Work with local and remote cross-functional teams; communicate experimental status and technical observations.
- Document work accurately; monitor QC measures to ensure data integrity and compliance with lab standards.
- Stay current with advances in single-cell/spatial genomics and help integrate best practices into lab workflows.
Essential Requirements
- MS (or BS + 2 years experience) in Molecular Biology, Genomics, Biochemistry, or related field (or equivalent experience).
- 1–2 years hands-on experience with spatial transcriptomics and/or single-cell sequencing.
- Knowledge of molecular biology techniques including PCR, qRT-PCR, enzymatic reactions, DNA/RNA purification and manipulation.
- Experience troubleshooting and optimizing protocols (with guidance) for complex genomics assays.
- Knowledge of NGS library preparation and sequencing workflows.
Desirable Requirements
- Experience with tissue processing, imaging, IHC, and microscopy.
Application Instructions
- Submit a CV and cover letter summarizing relevant experience with single-cell and spatial omics protocols and instrumentation.