Research Scientist
Jazz Pharmaceuticals
4 hours ago
On-site
Durham, NC
Clinical Research and Development
Brief Description
- Design and execute experiments on the efficacy and mechanism of action of anticancer compounds with limited supervision, focusing on receptor tyrosine kinases (RTKs), preferably HER2.
- Document and archive experimental protocols, data, analyses, and conclusions per established laboratory procedures.
- Communicate research through publications, conference presentations, abstracts, and patent applications.
- Full-time laboratory-based position.
Essential Functions/Responsibilities
- Manage cell culture of cancer and normal cell lines.
- Perform in vitro efficacy, mechanism of action, target validation, and biomarker studies with cancer therapeutics, emphasizing RTK/HER2-driven models.
- Create stable cell lines with CRISPR and inducible expression, including lines engineered to modulate RTK/HER2 signaling.
- Create or adapt reporter systems for relevant molecular targets.
- Present summary results for internal communications and external presentations.
- Support preparation of conference abstracts and manuscripts for publication as needed.
- Develop operational, data documentation, and troubleshooting procedures.
- Perform other assigned responsibilities and projects.
Required Knowledge, Skills, and Abilities
- Routine laboratory work; able to sit/stand at a computer and type for extended periods; uses office equipment; occasional movement within office; occasional lifting up to 25 pounds.
- 3+ years of industry or post-doctoral oncology experience.
- Demonstrated expertise in RTK biology (preferably HER2), including characterization of RTK signaling, pathway modulation, and therapeutic mechanisms of action.
- Experience with oncology and pharmacology assays and techniques.
- Exceptional written and verbal communication (publications and conference presentations).
- Organized team player managing multiple concurrent projects with minimal oversight.
- Forward-thinking; anticipates challenges and implements solutions.
- Computer proficient; drives advancement of numerous projects simultaneously.
- Ability to identify/initiate tasks, set goals, create timelines, and monitor progress.
- Strong urgency; positive hands-on approach; responds professionally to changing priorities.
- Experience working in a matrix, cross-functional environment.
- Strong written/oral communication and ability to work independently with high attention to detail.
Required/Preferred Education and Licenses
- Ph.D. in cancer biology, molecular/cell biology, biochemistry, pharmacology, or related fields, or master’s degree with relevant experience.
Benefits (US candidates only, if applicable)
- Eligible for medical, dental, and vision insurance; 401(k) retirement savings plan; and flexible paid vacation.
Application instructions
- If you are a current Jazz employee, apply via the Internal Career site.
- Design and execute experiments on the efficacy and mechanism of action of anticancer compounds with limited supervision, focusing on receptor tyrosine kinases (RTKs), preferably HER2.
- Document and archive experimental protocols, data, analyses, and conclusions per established laboratory procedures.
- Communicate research through publications, conference presentations, abstracts, and patent applications.
- Full-time laboratory-based position.
Essential Functions/Responsibilities
- Manage cell culture of cancer and normal cell lines.
- Perform in vitro efficacy, mechanism of action, target validation, and biomarker studies with cancer therapeutics, emphasizing RTK/HER2-driven models.
- Create stable cell lines with CRISPR and inducible expression, including lines engineered to modulate RTK/HER2 signaling.
- Create or adapt reporter systems for relevant molecular targets.
- Present summary results for internal communications and external presentations.
- Support preparation of conference abstracts and manuscripts for publication as needed.
- Develop operational, data documentation, and troubleshooting procedures.
- Perform other assigned responsibilities and projects.
Required Knowledge, Skills, and Abilities
- Routine laboratory work; able to sit/stand at a computer and type for extended periods; uses office equipment; occasional movement within office; occasional lifting up to 25 pounds.
- 3+ years of industry or post-doctoral oncology experience.
- Demonstrated expertise in RTK biology (preferably HER2), including characterization of RTK signaling, pathway modulation, and therapeutic mechanisms of action.
- Experience with oncology and pharmacology assays and techniques.
- Exceptional written and verbal communication (publications and conference presentations).
- Organized team player managing multiple concurrent projects with minimal oversight.
- Forward-thinking; anticipates challenges and implements solutions.
- Computer proficient; drives advancement of numerous projects simultaneously.
- Ability to identify/initiate tasks, set goals, create timelines, and monitor progress.
- Strong urgency; positive hands-on approach; responds professionally to changing priorities.
- Experience working in a matrix, cross-functional environment.
- Strong written/oral communication and ability to work independently with high attention to detail.
Required/Preferred Education and Licenses
- Ph.D. in cancer biology, molecular/cell biology, biochemistry, pharmacology, or related fields, or master’s degree with relevant experience.
Benefits (US candidates only, if applicable)
- Eligible for medical, dental, and vision insurance; 401(k) retirement savings plan; and flexible paid vacation.
Application instructions
- If you are a current Jazz employee, apply via the Internal Career site.