Research Associate Scientist, Immuno-Oncology Biology (ODDU)

Role Summary

Research Associate Scientist, Immuno-Oncology Biology (ODDU) — Cambridge, MA. Focus on in vivo efficacy, PK, and MOA studies across multiple models; contribute to data interpretation, protocol development, and IND documentation.

Responsibilities

• Design and implement in vivo experiments focusing on efficacy, pharmacokinetics (PK), and mechanism of action (MOA) studies in syngeneic, xenograft, and patient-derived xenograft (PDX) models.
• Perform standard and complex in vivo procedures including dosing via all routes, tissue necropsy, tumor inoculation and measurements.
• Analyze, interpret, and present technical or project data to stakeholders; participate in scientific discussions and decision-making.
• Collaborate externally with Contract Research Organizations (CROs) and establish new protocols.
• Identify experimental protocols and in vivo models; conduct immunoassays such as flow cytometry, cytotoxicity assays, MSD assays, and Western blotting.
• Plan and execute well-defined scientific projects with minimal supervision; deliver high-quality data to inform decision-making; communicate program strategy and timelines to management.
• Maintain laboratory notebooks and ensure compliance with laboratory practices.
• Contribute to Investigational New Drug (IND) reports and documentation.
• Remote work up to 20% as allowed.

Qualifications

• Required: Master’s degree in Biotechnology, Animal Science, Biochemistry, Biology, or related field with 3 years of related experience, OR Bachelor’s degree in those fields with 5 years of related experience.
• Experience requirements include: development of in vivo mouse models and execution of in vivo animal work (tumor inoculation SC/IP, T cell dosing and administration IV, tumor measurement, tissue collection and ex vivo processing); multi-color flow cytometry and data analysis of tumor tissues, tumor cell lines, and human T cells; immunoassays including cytotoxicity assays, repeat stimulation assays, and MSD assays; mentoring/training teammates in lab techniques; maintaining tumor cell lines and human primary cell cultures; DNA/RNA extraction with PCR, gel electrophoresis, and DNA sequencing.

Skills

• In vivo experimentation in oncology models
• Flow cytometry and data analysis
• Immunoassays (cytotoxicity, MSD, Western blotting)
• Project planning and scientific communication
• Lab notebook maintenance and compliance
• Collaborative work with CROs

Education

• Master’s or Bachelor’s degree in Biotechnology, Animal Science, Biochemistry, Biology, or related field (as per qualifications above).

Additional Requirements

• Full-time role; up to 20% remote work allowed.