Research Associate II – Bioanalytical/In Vitro ADME/DMPK

Position: Research Associate II (Bioanalytical-In Vitro DMPK) — onsite at Nurix headquarters in Brisbane, CA.

Responsibilities:
- Provide bioanalytical support for in-house PK, non-GLP safety TK
- Conduct bioanalytical method development and qualification for drug, metabolite, and biomarker analysis
- Independently develop LC-MS/MS methods to quantitate small molecules in in vitro and in vivo samples
- Conduct in-vitro stability assays to understand drug metabolism
- Perform metabolic identification (MetID) using LC-QTOF MS/MS (accurate mass analysis, fragment interpretation, biotransformation pathway assignment)
- Independently operate, troubleshoot, and maintain LC-MS/MS systems
- Collaborate with multidisciplinary teams to support PK/PD needs
- Manage CRO projects to deliver high-quality bioanalytical data on timelines
- Maintain accurate scientific electronic lab notebooks

Preferred Qualifications & Experience:
- Experience with H/UPLC and mass spectrometry
- Working knowledge of SCIEX LC-MS/MS systems
- PK analysis using Phoenix or other data management software
- CRO management experience for outsourcing BA activities
- Experience supporting PK, PK/PD, distribution, metabolism, and non-GLP toxicology studies
- Ability to troubleshoot LC-MS/MS equipment and develop/execute methods and reports
- Excellent oral and written communication

Requirements:
- BS or master’s with >4 years’ experience in a pharmaceutical/biotechnology discovery setting using LC-MS/MS
- Broad LC-MS/MS bioanalytical assay development/sample analysis across biological matrices
- Experience with AB SCIEX mass spectrometry software
- Excellent written/verbal and interpersonal skills for internal/external collaboration

Salary Range: $92,891 - $106,507

Application Process:
- Applicants must be legally entitled to work for any employer in the US.