Research Associate I / Research Associate II, Manufacturing Process Research
Ionis Pharmaceuticals, Inc.
August 14, 2026
Remote friendly (Carlsbad, CA)
United States
Operations
Position: Research Associate I / Research Associate II, Manufacturing Process Research
Work Location: Carlsbad, CA
Responsibilities:
- Execute defined laboratory experiments supporting oligonucleotide process development and manufacturing research.
- Perform laboratory-scale solid-phase synthesis and related operations (e.g., coupling, oxidation, detritylation, deprotection, cleavage).
- Prepare, process, and purify oligonucleotide materials (e.g., chromatography, filtration, tangential flow filtration, annealing, concentration, isolation).
- Support process-development programs across modalities (e.g., antisense, siRNA, conjugated, modified oligonucleotides).
- Evaluate process conditions, materials/resins/reagents, and equipment settings under guidance.
- Prepare drug substance, intermediates, research materials, impurity samples, and analytical/manufacturing support samples.
- Collect/review experimental and analytical data; record results in electronic lab notebooks.
- Contribute to technical documents (reports, presentations, process summaries) under review.
- Operate lab equipment after training; maintain safety, data integrity, and organized lab operations.
- Support investigations into unexpected results; collaborate with cross-functional partners.
Qualifications:
Required:
- Bachelor’s degree in a relevant scientific field; Research Associate II requires at least 2 years relevant experience.
- Understanding of basic chemistry/lab practices and problem solving.
- Ability to follow procedures and maintain accurate records; communicate results.
- Attention to detail, strong communication skills, cross-functional collaboration.
- Ability to stand for extended periods; safe work with hazardous chemicals/biological/pharmaceutical materials; occasional schedule flexibility.
Preferred:
- Experience with oligonucleotides/nucleic acids/peptide conjugates or process chemistry/purification/pharma manufacturing.
- Familiarity with solid-phase synthesis, chromatography, filtration, tangential flow filtration, and/or lab-scale manufacturing.
- Exposure to HPLC, LC-MS, UV detection; use of ELN/LIMS/spreadsheets.
- Knowledge of GLP/GMP, chemical hygiene, data integrity; experience preparing technical reports/presentations.
Application Instructions:
- Apply on Ionis website and reference requisition # IONIS004100.
Work Location: Carlsbad, CA
Responsibilities:
- Execute defined laboratory experiments supporting oligonucleotide process development and manufacturing research.
- Perform laboratory-scale solid-phase synthesis and related operations (e.g., coupling, oxidation, detritylation, deprotection, cleavage).
- Prepare, process, and purify oligonucleotide materials (e.g., chromatography, filtration, tangential flow filtration, annealing, concentration, isolation).
- Support process-development programs across modalities (e.g., antisense, siRNA, conjugated, modified oligonucleotides).
- Evaluate process conditions, materials/resins/reagents, and equipment settings under guidance.
- Prepare drug substance, intermediates, research materials, impurity samples, and analytical/manufacturing support samples.
- Collect/review experimental and analytical data; record results in electronic lab notebooks.
- Contribute to technical documents (reports, presentations, process summaries) under review.
- Operate lab equipment after training; maintain safety, data integrity, and organized lab operations.
- Support investigations into unexpected results; collaborate with cross-functional partners.
Qualifications:
Required:
- Bachelor’s degree in a relevant scientific field; Research Associate II requires at least 2 years relevant experience.
- Understanding of basic chemistry/lab practices and problem solving.
- Ability to follow procedures and maintain accurate records; communicate results.
- Attention to detail, strong communication skills, cross-functional collaboration.
- Ability to stand for extended periods; safe work with hazardous chemicals/biological/pharmaceutical materials; occasional schedule flexibility.
Preferred:
- Experience with oligonucleotides/nucleic acids/peptide conjugates or process chemistry/purification/pharma manufacturing.
- Familiarity with solid-phase synthesis, chromatography, filtration, tangential flow filtration, and/or lab-scale manufacturing.
- Exposure to HPLC, LC-MS, UV detection; use of ELN/LIMS/spreadsheets.
- Knowledge of GLP/GMP, chemical hygiene, data integrity; experience preparing technical reports/presentations.
Application Instructions:
- Apply on Ionis website and reference requisition # IONIS004100.