Research Associate I/II, Oligonucleotide Synthesis & Chemistry

Role Summary

Wave Life Sciences seeks a motivated Research Associate I/II, Oligo Synthesis and Chemistry, to join our team in Lexington, MA. This role is ideal for individuals with a background in analytical chemistry who thrive in a team-oriented, fast-paced biotech environment. The candidate will fulfill compound requests to support discovery-related activities and ensure sample quality.

Responsibilities

• Enable timely fulfillment of compound requests while ensuring their accuracy and quality for in vitro/vivo assays
• Analysis of oligonucleotides by LC-MS and UHPLC for identification and purity assessment
• Operation of Hamilton Star liquid handler for high throughput sample preparation in 96-well assay plates
• Perform QC assays such as UV, pH, osmolality, and bacterial endotoxin
• Maintain an accurate and traceable oligonucleotide inventory
• Mentor co-ops on laboratory instrumentation and workflows
• Support general laboratory instrument maintenance and troubleshooting
• Communicate effectively with team members and requestors to enable screening efforts for multiple projects
• Document experimental results in ELN and register relevant sample data
• Interact with Data Science/IT to continually advance the data management systems as needed

Qualifications

• Required: Master’s Degree with 0-2 years of industry experience or Bachelor’s Degree with 2-4 years of industry experience
• Preferred: Analytical chemistry background

Skills

• Meticulous attention to detail and data integrity
• Excellent organizational and time management skills with ability to multitask
• Excellent communication and problem-solving skills
• Expertise with common laboratory operations, including accurate pipetting, dilution, and UV measurement
• Previous experience with UHPLC and LC-MS operation and analysis strongly preferred
• Previous compound formulation experience strongly preferred
• Understanding of oligonucleotide synthesis, formulation, and characterization preferred