Research Associate Co-Op, Protein Biochemistry

Company: Keros Therapeutics

At Keros, our mission is to deliver significant clinical benefit to a wide range of patients with disorders that are linked to dysfunctional signaling of the transforming growth factor-beta (TGF-ß) family of proteins. With a focus on developing differentiated product candidates that are designed to alter TGF-β signaling, we aim to target the pathways critical for the growth, repair and maintenance of blood cells and a number of tissues, including bone, skeletal muscle, adipose and heart tissue. We believe our product candidates have the potential to unlock the full therapeutic benefits of modulating the TGF-β superfamily and provide disease-modifying benefit to patients.

Job Summary

Keros Therapeutics is seeking a highly motivated and collaborative individual to join our protein biochemistry group within our Research Department. Our group exploits multidisciplinary approaches in protein sciences and protein engineering, to better the understanding of the biochemical, biophysical, and structural functional properties of the biomolecules within the TGF-β superfamily that drive the signaling pathway. Our efforts greatly contribute to advance innovative research and drug discovery and heavily support our discovery pipeline.

You will have the opportunity to learn about early-stage drug discovery from a protein chemistry perspective as well as through internal and external collaboration with other departments. You will play an important role supporting in vivo and in vitro studies crucial for the progress of our therapeutic research programs by generating high-quality proteins and other reagents in this hands-on laboratory position. The successful candidate will produce and evaluate novel molecules, while being inquisitive about science, able to troubleshoot by consulting literature/colleagues, and capable of adapting to each scientific challenge.

Primary Responsibilities

• Protein expression: assist with routine mammalian expression of our therapeutic molecules to support ongoing studies, assess novel drug candidates through transient expression with CHO and HEK cells, establish stable cell-lines of new drug candidates when necessary.
• Protein purification: purify proteins to required reagents’ quality (FPLC, affinity/ion-exchange/SEC and other chromatographic techniques).
• Protein characterization: Perform assays and other characterization techniques (cell-based, SPR, BLI assays, SDS-PAGE, Analytical SEC, HPLC) to characterize therapeutic and novel molecules.
• Maintain clear, accurate documentation of computational and experimental laboratory work and summarize results as needed in study reports.
• Provide updates at research meetings in both oral and written formats.

Core Competencies (Required Skills)

• Experience working with wet lab benchwork, lab etiquette, pipetting, and volumetric handling. Ability to perform chemical stoichiometric calculations and buffer preparation.
• Experience with protein expression in mammalian and/or bacterial cells is highly desirable.
• Ability to work as part of a cross-functional team and independently with supervision.
• Exhibit excellent communication and organization skills, detail-oriented, proficient in MS office, data analysis, and slide presentation.
• Displays a high degree of maturity, honesty, trust, and integrity. Considers a scientific problem/question an opportunity for innovation and intellectual growth.

Preferred Skills

• Experience in protein purification using multi-platform chromatography techniques (affinity, ion-exchange, SEC) and/or biophysical methods for protein characterization.
• Protein chemistry, protein-protein interactions, and/or protein engineering experience.
• Previous co-op or intern experience.

Education Requirements

• Enrolled in a master’s program in biochemistry, structural biology, chemistry, or a related discipline.

Our Diversity, Equity & Inclusion Mission Statement

Keros is an inclusive company. We believe that diversity drives innovation. We continue to build an inclusive culture that encourages, supports, and celebrates the diverse voices of our employees. As such, Keros takes a holistic approach in mentoring, coaching, and developing all of our Keros team members.

Keros Therapeutics is an Equal Opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex including sexual orientation and gender identity, national origin, disability, protected veteran status, or any other characteristic protected by applicable federal, state, or local law.

Recruitment & Staffing Agencies

Keros Therapeutics does not accept unsolicited resumes from any source other than the candidate directly. Any unsolicited submission by an agency to Keros is prohibited. Any resume submitted by an agency without a signed contract or expressed consent by a member of the Keros Therapeutics Human Resources Department will be considered property of Keros Therapeutics, and no fee shall be owed with respect thereto.