Madrigal Pharmaceuticals: Transforming Treatment for MASH

At Madrigal, we are committed to transforming treatment for patients with metabolic-dysfunction associated steatohepatitis (MASH). MASH will soon become the leading cause of liver transplantation in the U.S., but there are currently no approved medications to treat the disease.

Resmetirom is a once daily, oral, thyroid hormone receptor (THR)-β selective agonist that is designed to target key underlying causes of MASH in the liver. Positive results from the first of two Phase 3 clinical trials of resmetirom in MASH were announced in January 2022; and results from a second Phase 3 clinical trial in December of 2022. Rezdiffra (resmetirom) was approved in March 2024.

Madrigal has established its leadership position in MASH by staying true to its science-driven foundation and building a company culture based on collaboration and trust. Our team members are focused on delivering results for the benefit of healthcare providers, and most importantly, patients. These values will remain central to Madrigal as the company grows and evolves its commercial capabilities to prepare for a potential first-to-market launch in MASH.

Madrigal’s Commercial Team

Madrigal’s commercial team is in constant pursuit of excellence in all that we do. Conducting our business in an honest and transparent fashion is of the utmost importance to us. We have a “business owner” mentality and understand the responsibility and opportunity we have been given to promote a revolutionary therapy to patients and their healthcare providers. It is essential for the commercial team to have an in-depth and up-to-date knowledge of the resmetirom program and developments in MASH, as we answer the needs of the patients and physicians we serve with the approval and launch of resmetirom in the U.S.

Opportunity and Summary of Position

In this role, the Regional Sales Director will develop the regional business strategy, and hire and lead a team of high-performing Area Business Managers to achieve/exceed business and sales goals. You will work closely with Sales VP and collaborate with other senior leaders across the organization to develop and execute strategies and initiatives that contribute to the overall performance, culture and success of the organization.

The Regional Sales Director will be a working leader with a player/coach mentality. The successful candidate will participate in field-based activities; including but not limited to shared ownership of high value regional accounts, (e.g., large MASH-related group practices, etc.) and relationships with local thought leaders. The Regional Sales Director will be adept at understanding analytics, market research and local geographic trends to identify business opportunities and create comprehensive and detailed business plans for execution at launch. It is expected that this team member will display a high level of collaboration with colleagues/stakeholders to develop materials and customer-focused initiatives targeted for a diverse range of healthcare professionals.

Position Responsibilities

• Source, recruit and hire a team of Area Business Managers who are responsible for driving sales results while effectively and compliantly promoting company’s product(s) to targeted HCPs and other healthcare professionals.
• Drive performance of region and lead by example as a working leader, meeting with top regional accounts and HCPs/staff.
• Work collaboratively and compliantly with cross-functional field facing partners to develop internal and external customer focused initiatives and deliver a positive customer experience and engagement.
• Review and analyze district performance and market data in order to develop sales strategies to meet or exceed sales objectives.
• Drive performance while developing individual contributors on teams through an established coaching and development plan.
• Manage performance issues with parity and a sense of urgency.
• Ability to create culture that attracts and retains top talent while driving sales results.
• Lead by example to master and display high level of clinical acumen; accountability for self and team to demonstrate mastery level of clinical knowledge, including assessments.
• Demonstrate patient centric mindset.
• Monitor and ensure utilization of sales and marketing tools and other resources provided to educate healthcare professionals on company’s product(s).
• Establish and cultivate strategic relationships with physicians and other healthcare professionals within designated geography (working leader).
• Attend all company-sponsored sales and medical meetings as directed by management; attend live conferences and/or programs as necessary as a Madrigal representative.
• Comply with all legal, regulatory and compliance policies and demonstrate a high level of integrity and professionalism at all times.
• Spearhead cross-functional collaboration and serve as an advocate for customer engagement model.
• Additional duties as required.

Qualifications and Skills

• Bachelor's degree required.
• 2-5+ years of first-line management experience.
• 10+ years of pharmaceutical/biopharmaceutical, medical or related sales experience.
• MASH-related specialty experience (GI, Hepatology, Endocrinology experience) strongly preferred.
• Prior launch experience is required.
• Local experience, track record of success, and access to relevant regional thought leaders within assigned region strongly preferred.
• Ability to utilize performance and market data to create actionable business plans to drive sales results.
• Demonstrated track record of leading successful sales leaders and teams in an environment requiring a high level of initiative, accountability and ethical and compliant actions.
• Ability to learn complex scientific and technical information and effectively communicate to a broad audience of healthcare professionals.
• Strong communication skills, including proven ability to successfully influence in the virtual setting.
• Collaborative, working leader mindset.
• Proficiency with Microsoft Office Suite.
• A valid driver’s license and ability to travel as needed (including overnights and/or weekends) is required.
• Overnight travel up to 50-65% is expected, depending on regional boundaries.
• Frequent travel between meeting sites, requiring the ability to sit for extended periods of time.
• Frequent use of a computer, telephone, printer or other office equipment.
• Ability to lift up to 20 pounds.

Compensation

An attractive compensation package will be offered to the successful candidate. It will include a competitive base salary and incentive bonus. A benefits package customary to the position will also be provided including 401k match, medical and dental.

The base salary range will be $170,000-$200,000 per year.

Equal Opportunity Employer

Madrigal is an Equal Opportunity Employer. All employment is decided on the basis of qualifications, merit, and business need. Applicants will receive consideration for employment without regard to race, ethnicity, color, religion, sex gender identity, sexual orientation, national origin, age, disability, protected veteran or disabled status, or other characteristic protected by applicable federal, state, or local law.

Unsolicited resumes from agencies should not be forwarded to Madrigal. Madrigal will not be responsible for any fees arising from the use of resumes through this source. Madrigal will only pay a fee to agencies if a formal agreement between Madrigal and the agency has been established.

Fraud Warning

Please be aware that we are currently receiving numerous reports of individuals misrepresenting themselves as Madrigal Pharmaceuticals’ Hiring Managers, seeking to engage with job candidates through fraudulent online advertisements or job posting sites. These unauthorized individuals are using Madrigal’s name and logo in an attempt to solicit up-front fees and obtain personal information from interested job candidates. Please know that Madrigal does not conduct interviews via text or in chat rooms; conduct interviews via Skype, RingCentral or solely via telephone; charge candidates an advance fee of any kind (e.g., fees for purchasing equipment); nor does it offer positions of employment without undergoing a thorough recruiting process. Interviews with Madrigal are conducted via the Zoom platform.

Please also note that any correspondence with regard to employment would come from an authorized madrigalpharma.com email address or from an email address from one of our trusted search firm partners. We are aware that incorrect/fraudulent email addresses, with Madrigal misspelled, have been utilized in these most recent fraud attempts. If you receive unsolicited employment offers from people claiming to work for Madrigal we recommend that you: do not respond to their questions; do not open any attachments; and do not click on any hyperlinks.

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