QSP postdoctoral scientist
Eli Lilly and Company
August 08, 2026
Remote friendly (Indianapolis, IN)
United States
Clinical Research and Development
Position Overview
Postdoctoral scientist (Global PKPD) developing Quantitative Systems Pharmacology (QSP) models; collaborate with cross-functional teams to develop and apply AI-powered QSP models integrating biology, pharmacology, and preclinical/clinical data.
Primary Responsibilities
- Conduct literature, regulatory, and database searches to compile preclinical/clinical data for model design and parameterization.
- Design and implement ODE-based QSP model structures capturing drug PK, target/receptor biology, and cellular/physiological dynamics.
- Perform parameter estimation, simulations, and model analysis to support timely drug discovery/development decisions.
- Use validated models to generate insights for dosing strategies, risk stratification, and translational/clinical questions.
- Communicate results to technical and non-technical audiences; collaborate cross-functionally.
- Maintain documentation; present at scientific conferences; author peer-reviewed articles.
Basic Qualifications / Required
- PhD in quantitative pharmacology, systems biology, biomedical engineering, applied mathematics, or related field.
- Experience developing QSP/mechanistic PKPD or ODE-based biological system models.
- Experience developing virtual patient populations.
- Proficiency in R, Matlab/Simbiology, Python, NONMEM, Monolix, or related modeling software.
- Experience with parameter estimation and sensitivity analysis.
- Authorized to work in the United States full-time; Lilly does not sponsor visas/work authorization.
Preferred Skills
- Knowledge of T cell engager bispecifics and immunology; PK/PD and drug discovery/development.
- Interest in AI/ML integration; strong problem-solving, organization, communication; strong publication record.
Additional Information / Benefits
- Fixed-term 2 years (potential to extend to 3 years).
- Anticipated wage: $58,000–$123,200; full-time roles may be eligible for bonus and comprehensive benefits (e.g., 401(k), medical/dental/vision, life insurance, time off, well-being).
Postdoctoral scientist (Global PKPD) developing Quantitative Systems Pharmacology (QSP) models; collaborate with cross-functional teams to develop and apply AI-powered QSP models integrating biology, pharmacology, and preclinical/clinical data.
Primary Responsibilities
- Conduct literature, regulatory, and database searches to compile preclinical/clinical data for model design and parameterization.
- Design and implement ODE-based QSP model structures capturing drug PK, target/receptor biology, and cellular/physiological dynamics.
- Perform parameter estimation, simulations, and model analysis to support timely drug discovery/development decisions.
- Use validated models to generate insights for dosing strategies, risk stratification, and translational/clinical questions.
- Communicate results to technical and non-technical audiences; collaborate cross-functionally.
- Maintain documentation; present at scientific conferences; author peer-reviewed articles.
Basic Qualifications / Required
- PhD in quantitative pharmacology, systems biology, biomedical engineering, applied mathematics, or related field.
- Experience developing QSP/mechanistic PKPD or ODE-based biological system models.
- Experience developing virtual patient populations.
- Proficiency in R, Matlab/Simbiology, Python, NONMEM, Monolix, or related modeling software.
- Experience with parameter estimation and sensitivity analysis.
- Authorized to work in the United States full-time; Lilly does not sponsor visas/work authorization.
Preferred Skills
- Knowledge of T cell engager bispecifics and immunology; PK/PD and drug discovery/development.
- Interest in AI/ML integration; strong problem-solving, organization, communication; strong publication record.
Additional Information / Benefits
- Fixed-term 2 years (potential to extend to 3 years).
- Anticipated wage: $58,000–$123,200; full-time roles may be eligible for bonus and comprehensive benefits (e.g., 401(k), medical/dental/vision, life insurance, time off, well-being).