Protein Scientist, Assistant Director or Associate Director
Ionis Pharmaceuticals, Inc.
September 05, 2026
Full-time
Remote friendly (Carlsbad, CA)
Worldwide
Clinical Research and Development
Role: Lead protein discovery and engineering efforts supporting protein-oligonucleotide conjugate programs, focusing on developing robust, scalable protein fusion constructs for therapeutic applications. Responsibilities: design, express, purify, and characterize protein ligands and fusion proteins; optimize candidates from primary screening; develop production strategies; collaborate with chemistry and development teams to ensure conjugation compatibility; oversee analytical assessments; mentor junior staff; present findings to teams and leadership. Requirements: PhD in relevant fields; 5+ years (Assistant Director) or 8+ years (Associate Director) industry experience; extensive hands-on expertise in recombinant expression in microbial and mammalian systems; proven track record in protein engineering, construct optimization, and molecule progression from discovery to scale-up; strong analytical and problem-solving skills; excellent communication. HighValue: bioconjugation, protein engineering, ligand discovery, scale-up, therapeutic proteins, RNA-targeted modalities, preclinical to clinical development. Preferred: experience with protein constructs for conjugation, structure-guided design, computational tools, protein scale-up for preclinical studies, cross-functional leadership. WorkSetup: likely hybrid with potential for onsite collaboration; no specific travel mentioned.