Project Toxicologist, Director – Oncology Targeted Delivery (OTD) Safety Science, Clinical Pharmacology and Safety Sciences (Cambridge, MA or Gaithersburg, MD)

Role: Director, Project Toxicologist within AstraZeneca's Oncology Targeted Delivery Safety team, specializing in novel targeted oncology therapies such as radioconjugates, ADCs, and small molecules. Responsibilities: lead toxicology strategies including designing and overseeing regulatory and investigative programs, supporting development decisions through safety risk assessment, advancing safety science via innovative approaches like organ-on-chip and omics, and contributing to regulatory submissions. Engage in external collaborations, provide scientific leadership, and support team development. Requirements: PhD, DABT, or advanced degree in toxicology, pharmacology, or related field with at least 10 years of experience in project, investigative, or regulatory toxicology within pharma, biotech, or CRO sectors. Oncology expertise required, with preferred experience in radioconjugates or ADCs. Skills in translational safety tools and cross-functional collaboration are essential. HighValue: Oncology (radioconjugates, ADCs, small molecules), drug discovery and development, IND support, regulatory toxicology, innovative safety assessment technologies. Location: Cambridge, MA or Gaithersburg, MD, with in-person work and some travel. The role emphasizes scientific influence, strategic thinking, and leadership in early to late-stage oncology safety evaluation.