Process Engineer, Kilo and High Potency Lab, Lilly Medicine Foundry
Eli Lilly and Company
August 19, 2026
On-site
Indianapolis, IN
Operations
Responsibilities:
- Evaluate scale-up feasibility and rig fit for new chemistries using technical data packages plus kinetic/mass-transfer/heat-transfer modeling and experiments to transfer from gram- to kilogram-scale reactors.
- Design, test, and install new equipment to meet evolving portfolio and reaction needs.
- Design, operate, and troubleshoot kilo-scale reactor systems (glass-lined/Hastelloy reactors, agitated filter-dryers) and support plant design for piping, mixing, heat transfer, and automation.
- Engineer containment and safe-handling strategies for HPAPI operations (isolators/glove boxes, OEB, dry-end solids processing).
- Optimize crystallization, distillation, extraction, and isolation unit operations; resolve polymorphism/particle-size issues; close mass balances and track impurity fate/purge.
- Safeguard quality, safety, and cGMP compliance; author/review technical reports, regulatory submissions, and lab notebooks.
- Drive cross-functional execution via impact/risk assessments and project plans with a proactive quality mindset.
- Develop or review plans and timetables for project work.
Basic Requirements:
- BS or MS in chemical engineering (or related) with 1–4 years’ experience in pharma/biotech/CMO supporting API process engineering or development.
- Authorized to work in the United States full-time; no visa sponsorship.
Additional Preferences:
- Process development/chemical engineering interest; team collaboration with accountability.
- Experience with DeltaV, Dynochem, Aspen, and/or electronic lab notebooks.
- Kilo-scale equipment and scale-up factors (kinetics, mass transfer, heat transfer).
- HPAPI handling/containment (isolators, glove boxes) and OEB practices.
- Organic unit ops and analytics (HPLC/UPLC, MS, NMR, GC, KF, DSC, XRD) in cGMP gram-to-kilogram scale-up.
- Bioconjugate unit ops (single use, TFF, chromatography); strong analytical/problem-solving and communication.
Other Information:
- Initial location: Parkwood West, Indianapolis.
- Permanent location: Lilly Medicine Foundry, Lebanon, Indiana.
- Evaluate scale-up feasibility and rig fit for new chemistries using technical data packages plus kinetic/mass-transfer/heat-transfer modeling and experiments to transfer from gram- to kilogram-scale reactors.
- Design, test, and install new equipment to meet evolving portfolio and reaction needs.
- Design, operate, and troubleshoot kilo-scale reactor systems (glass-lined/Hastelloy reactors, agitated filter-dryers) and support plant design for piping, mixing, heat transfer, and automation.
- Engineer containment and safe-handling strategies for HPAPI operations (isolators/glove boxes, OEB, dry-end solids processing).
- Optimize crystallization, distillation, extraction, and isolation unit operations; resolve polymorphism/particle-size issues; close mass balances and track impurity fate/purge.
- Safeguard quality, safety, and cGMP compliance; author/review technical reports, regulatory submissions, and lab notebooks.
- Drive cross-functional execution via impact/risk assessments and project plans with a proactive quality mindset.
- Develop or review plans and timetables for project work.
Basic Requirements:
- BS or MS in chemical engineering (or related) with 1–4 years’ experience in pharma/biotech/CMO supporting API process engineering or development.
- Authorized to work in the United States full-time; no visa sponsorship.
Additional Preferences:
- Process development/chemical engineering interest; team collaboration with accountability.
- Experience with DeltaV, Dynochem, Aspen, and/or electronic lab notebooks.
- Kilo-scale equipment and scale-up factors (kinetics, mass transfer, heat transfer).
- HPAPI handling/containment (isolators, glove boxes) and OEB practices.
- Organic unit ops and analytics (HPLC/UPLC, MS, NMR, GC, KF, DSC, XRD) in cGMP gram-to-kilogram scale-up.
- Bioconjugate unit ops (single use, TFF, chromatography); strong analytical/problem-solving and communication.
Other Information:
- Initial location: Parkwood West, Indianapolis.
- Permanent location: Lilly Medicine Foundry, Lebanon, Indiana.