Principle Scientist Investigative Toxicology
Eli Lilly and Company
6 months ago
On-site
Indianapolis, IN
Clinical Research and Development
Principal Scientist – Investigative Toxicology
Position Overview
- Hands-on laboratory role generating high-quality in vitro data to support mechanism-based toxicology investigations and candidate selection across the drug discovery pipeline.
Key Responsibilities
- Perform routine mammalian cell culture (maintenance, expansion, experimental execution) using established cell lines and cellular systems.
- Implement biochemical, molecular, and cellular assays for mechanistic investigation of potential toxicities, including protein/gene expression analysis (Western blotting, qPCR), ELISAs, microscopy-based assays, and cell-based functional assays.
- Support non-GLP investigative toxicology studies by generating, documenting, and organizing high-quality in vitro data.
- Contribute to studies evaluating organ-specific toxicities (e.g., gastrointestinal, hematopoietic, dermal, or other target-relevant systems) using cell-based and emerging in vitro models.
- Maintain accurate electronic laboratory notebooks (data integrity, traceability, internal standards).
- Assist with data analysis, figure preparation, and summarization of results for internal reports/presentations.
- Collaborate with internal scientists and support internally led collaborations with external CRO partners (when appropriate).
- Follow laboratory safety, quality, and compliance guidelines.
Required Qualifications
- Bachelor’s with 5 years or Master’s with 3 years experience in Cell Biology, Molecular Biology, Biochemistry, Toxicology, or related discipline.
- Mammalian cell culture experience from academic research, industry, or internships.
- Biochemical/molecular techniques experience (Western blotting, qPCR, cell-based assays, fluorescence/confocal microscopy).
Preferred Qualifications
- Ability to follow protocols, troubleshoot routine experiments, and work independently with appropriate supervision.
- Strong organization and attention to detail; clear experimental records.
- Effective written and verbal communication.
- Prior industry/CRO laboratory experience.
- Exposure to toxicology, pharmacology, or drug discovery research.
- Familiarity with routine and emerging in vitro safety assessment models.
- Experience in highly collaborative, team-based research settings.
Benefits
- Anticipated wage: $65,250 - $169,400.
- Company bonus (for full-time equivalent employees).
- Comprehensive benefits program (e.g., 401(k), pension, vacation, medical/dental/vision/prescription, flexible benefits, life insurance, time off/leave, well-being benefits).
Application Instructions
- If you require accommodation to submit a resume, complete the workplace accommodation request form: https://careers.lilly.com/us/en/workplace-accommodation.
Position Overview
- Hands-on laboratory role generating high-quality in vitro data to support mechanism-based toxicology investigations and candidate selection across the drug discovery pipeline.
Key Responsibilities
- Perform routine mammalian cell culture (maintenance, expansion, experimental execution) using established cell lines and cellular systems.
- Implement biochemical, molecular, and cellular assays for mechanistic investigation of potential toxicities, including protein/gene expression analysis (Western blotting, qPCR), ELISAs, microscopy-based assays, and cell-based functional assays.
- Support non-GLP investigative toxicology studies by generating, documenting, and organizing high-quality in vitro data.
- Contribute to studies evaluating organ-specific toxicities (e.g., gastrointestinal, hematopoietic, dermal, or other target-relevant systems) using cell-based and emerging in vitro models.
- Maintain accurate electronic laboratory notebooks (data integrity, traceability, internal standards).
- Assist with data analysis, figure preparation, and summarization of results for internal reports/presentations.
- Collaborate with internal scientists and support internally led collaborations with external CRO partners (when appropriate).
- Follow laboratory safety, quality, and compliance guidelines.
Required Qualifications
- Bachelor’s with 5 years or Master’s with 3 years experience in Cell Biology, Molecular Biology, Biochemistry, Toxicology, or related discipline.
- Mammalian cell culture experience from academic research, industry, or internships.
- Biochemical/molecular techniques experience (Western blotting, qPCR, cell-based assays, fluorescence/confocal microscopy).
Preferred Qualifications
- Ability to follow protocols, troubleshoot routine experiments, and work independently with appropriate supervision.
- Strong organization and attention to detail; clear experimental records.
- Effective written and verbal communication.
- Prior industry/CRO laboratory experience.
- Exposure to toxicology, pharmacology, or drug discovery research.
- Familiarity with routine and emerging in vitro safety assessment models.
- Experience in highly collaborative, team-based research settings.
Benefits
- Anticipated wage: $65,250 - $169,400.
- Company bonus (for full-time equivalent employees).
- Comprehensive benefits program (e.g., 401(k), pension, vacation, medical/dental/vision/prescription, flexible benefits, life insurance, time off/leave, well-being benefits).
Application Instructions
- If you require accommodation to submit a resume, complete the workplace accommodation request form: https://careers.lilly.com/us/en/workplace-accommodation.