Principal Scientist, Translational Clinical Biomarkers

Role: Principal Scientist providing strategic biomarker leadership within Neuroscience drug development, spanning early to late clinical phases. Responsibilities include developing integrated biomarker strategies aligned with disease biology and therapeutic mechanisms, translating hypotheses into measurable approaches, and informing program decisions such as target engagement, patient stratification, and response assessment. The role involves cross-functional collaboration with Discovery, Clinical, Regulatory, and Data Science teams, interpreting complex datasets, and guiding biomarker technology evaluations. Qualifications: Ph.D., M.D., or equivalent with 10+ years in neuroscience, translational medicine, or biomarker science; proven experience leading biomarker strategies in drug development; expertise in neurodegeneration, neurobiology, or psychiatric disorders. Skills include biomarker discovery, clinical study design, data analysis, and scientific communication. Preferred skills encompass supporting multiple clinical stages, neurodegenerative indications (e.g., Alzheimer’s, Parkinson’s), and mentorship experience. The position is hybrid, based in the US, with approximately 10% travel. High-value specifics include focus on translational and clinical biomarker strategies relevant to neuroscience, neurodegeneration, and personalized medicine.