Principal Scientist, Toxicology
PTC Therapeutics, Inc.
August 22, 2026
Remote friendly (Bridgewater, NJ)
United States
Clinical Research and Development
Job Description Summary
The Principal Scientist, Toxicology is responsible for the design and oversight of nonclinical safety studies of development candidates. Works independently to plan, execute and interpret nonclinical safety studies. Communicates relevant safety information and acts as a toxicology representative with Project teams, Collaborators, and CROs. Works cross-functionally with internal departments and external resources on nonclinical safety-related issues.
Primary Duties/Responsibilities
- Designs and oversees studies supporting the nonclinical development program for development candidate compounds.
- Develops protocols; monitors studies; reviews, revises, and issues required reports for the nonclinical program.
- Writes/prepares regulatory documents, including toxicology sections of briefing books, INDs, and investigator brochures (IBs).
- Acts as a toxicology representative with collaborators and contract research organizations.
- Performs other tasks/assignments as specified by management.
Qualifications (Required)
- Ph.D. in Toxicology (or related discipline) and at least 7 years of experience with progressively increasing responsibilities in a pharmaceutical/biotechnology or related environment.
Skills/Knowledge (Required)
- Hands-on experience with nonclinical safety studies.
- GLP-compliant study conduct experience.
- US and international regulatory knowledge for nonclinical safety study design/conduct.
- Ability to write scientific documents and reports (protocols, reports, regulatory submissions).
- Proficiency with Microsoft Office.
- Excellent verbal and written communication.
- Ability to work independently and collaboratively in a fast-paced, matrixed environment.
- Analytical, problem-solving, adaptable to changing priorities.
- Strong planning, organization, and time management; supports multiple projects.
Preferred
- Diplomate of the American Board of Toxicology (DABT).
- Experience with orphan diseases.
Travel Requirements
- 10–25%.
Expected Base Salary Range
- $165,000–$185,000. Eligible for short- and long-term incentives; medical, dental, vision, and retirement savings plans.
Application Instructions
- Click here to return to the careers page.
The Principal Scientist, Toxicology is responsible for the design and oversight of nonclinical safety studies of development candidates. Works independently to plan, execute and interpret nonclinical safety studies. Communicates relevant safety information and acts as a toxicology representative with Project teams, Collaborators, and CROs. Works cross-functionally with internal departments and external resources on nonclinical safety-related issues.
Primary Duties/Responsibilities
- Designs and oversees studies supporting the nonclinical development program for development candidate compounds.
- Develops protocols; monitors studies; reviews, revises, and issues required reports for the nonclinical program.
- Writes/prepares regulatory documents, including toxicology sections of briefing books, INDs, and investigator brochures (IBs).
- Acts as a toxicology representative with collaborators and contract research organizations.
- Performs other tasks/assignments as specified by management.
Qualifications (Required)
- Ph.D. in Toxicology (or related discipline) and at least 7 years of experience with progressively increasing responsibilities in a pharmaceutical/biotechnology or related environment.
Skills/Knowledge (Required)
- Hands-on experience with nonclinical safety studies.
- GLP-compliant study conduct experience.
- US and international regulatory knowledge for nonclinical safety study design/conduct.
- Ability to write scientific documents and reports (protocols, reports, regulatory submissions).
- Proficiency with Microsoft Office.
- Excellent verbal and written communication.
- Ability to work independently and collaboratively in a fast-paced, matrixed environment.
- Analytical, problem-solving, adaptable to changing priorities.
- Strong planning, organization, and time management; supports multiple projects.
Preferred
- Diplomate of the American Board of Toxicology (DABT).
- Experience with orphan diseases.
Travel Requirements
- 10–25%.
Expected Base Salary Range
- $165,000–$185,000. Eligible for short- and long-term incentives; medical, dental, vision, and retirement savings plans.
Application Instructions
- Click here to return to the careers page.