Principal Scientist/Sr. Principal Scientist - Bioconjugation Process Development

Role Summary

Principal Scientist/Sr. Principal Scientist - Bioconjugation Process Development

Responsibilities

• Establish a productive laboratory program by directly designing and executing internal research plans, collaborate with teammates to analyze the results, form conclusions, propose logical next steps, and report findings to a larger team.
• Learn and apply new skills such as bioconjugation, purification screening, OFAT and Design of Experiment methodology, and analytical sample analysis.
• Operate at the interface between disciplines and departments to quickly move from one scientific challenge to another while navigating ambiguity.
• Perform fundamental and detailed studies of each process step for bioconjugation development.
• Perform scale-up demonstrations of bioconjugation processes and purifications to provide material and information for development purposes.
• Propose and test new methods to achieve bioconjugation and bioconjugate development. Collaborate and share findings with partners.
• Strong oral and written communication skills are expected.
• Perform necessary documentation work such as electronic notebook maintenance, report authoring and regulatory/manufacturing documentation.
• Bring new and useful concepts, methods, and ideas for how research can be improved and share these to make our group better.
• Demonstrate learning agility across modalities (e.g. small molecule, peptide and oligonucleotide).
• Help formulate commercial manufacturing strategy and collaborate with manufacturing partners to deliver robust processes that are ultimately suitable for large-scale production.

Qualifications

• BS with 6+ years of relevant experience or Master’s degree with 3+ years of relevant experience in synthetic organic chemistry, biochemistry, chemical biology, chemical engineering or related field.
• Experience with small molecule organic synthesis, knowledge of reaction mechanisms, and design of reactions.
• Experience with performing bioconjugation reactions at small-scale.
• Knowledge of basic antibody class, structure, and function.
• Knowledge of and hands-on experience with analytical methods used for small molecules and biomolecules (RP-HPLC, SEC, IEX, HIC, LC-MS, CE-SDS).
• Good interpersonal skills and a persistent tendency for collaboration.
• Demonstrated self-initiative and appropriate risk-taking behaviors.
• Ability to prioritize multiple activities and thrive in a setting that requires quick movement between scientific challenges and comfort with ambiguity.
• An active scientific curiosity and interest in complementary disciplines within the pharmaceutical industry.
• Hands-on experience with liquid chromatography: bioconjugate purification and familiarity with chromatography systems.

Skills

• Bioconjugation, purification screening, experimental design (OFAT and DOE), analytical sample analysis
• Interdisciplinary collaboration and communication
• Laboratory documentation and regulatory/manufacturing documentation
• Small molecule synthesis and bioconjugation techniques
• Analytical methods: RP-HPLC, SEC, IEX, HIC, LC-MS, CE-SDS

Education

• BS in a related field with 6+ years of experience or Master’s degree with 3+ years of experience in synthetic organic chemistry, biochemistry, chemical biology, chemical engineering or related field

Additional Requirements

• Travel: 0–10%
• Location: Indianapolis, Indiana, Lilly Technology Center – North
• Full-time salaried position