Principal Scientist/ Senior Principal Scientist, Large Molecule Biology
Eli Lilly and Company
June 25, 2026
On-site
New York, NY
Clinical Research and Development
Responsibilities:
- Design and execute in vitro and ex vivo studies advancing priority oncology targets through the drug discovery pipeline.
- Execute in vitro pharmacology assays to evaluate tumor cell signaling, antibody binding/internalization, cytotoxicity, effector function, cytokine release, and other cellular responses for medium/high-throughput screening.
- Develop, validate, and run bioanalytical assays; maintain, culture, and passage multiple cell lines.
- Conduct multiparameter flow cytometry and other in vitro/ex vivo assays (e.g., receptor occupancy/density, PK/PD, tumor isolation, blood cell analysis) to characterize binding interactions and cellular responses.
- Oversee third-party collaborator/vendor experimental work and partner with project/senior leaders to advance molecules.
- Present findings to technical and non-technical stakeholders via preclinical reports, team meetings, and presentations.
Basic Requirements:
- B.S. in Biology, Chemistry, Pharmacology, or related with 5+ years relevant experience, or M.S. with 3+ years (level based on experience).
- Authorized to work in the United States full-time; Lilly does not sponsor work authorization/visas.
Additional Skills/Preferences:
- Mammalian cell culture expertise; extensive in vitro/ex vivo assay experience.
- Strong in vitro pharmacology/data analysis; ability to design/execute experimental plans on schedule.
- Cross-disciplinary collaboration; excellent written/verbal communication and interpersonal skills.
- Biologic modality experience (mAbs, ADCs, CD3-engaging platforms).
- Multiparameter flow cytometry (panel design and data analysis).
- Experience developing/validating bioanalytical assays; independent leadership of multiple research programs with minimal supervision.
- Managing external collaborations/CROs; presenting to technical and non-technical audiences.
- Knowledge/interest in cancer disease states.
Additional Information:
- Location: New York, NY. Travel: <10%.
- Design and execute in vitro and ex vivo studies advancing priority oncology targets through the drug discovery pipeline.
- Execute in vitro pharmacology assays to evaluate tumor cell signaling, antibody binding/internalization, cytotoxicity, effector function, cytokine release, and other cellular responses for medium/high-throughput screening.
- Develop, validate, and run bioanalytical assays; maintain, culture, and passage multiple cell lines.
- Conduct multiparameter flow cytometry and other in vitro/ex vivo assays (e.g., receptor occupancy/density, PK/PD, tumor isolation, blood cell analysis) to characterize binding interactions and cellular responses.
- Oversee third-party collaborator/vendor experimental work and partner with project/senior leaders to advance molecules.
- Present findings to technical and non-technical stakeholders via preclinical reports, team meetings, and presentations.
Basic Requirements:
- B.S. in Biology, Chemistry, Pharmacology, or related with 5+ years relevant experience, or M.S. with 3+ years (level based on experience).
- Authorized to work in the United States full-time; Lilly does not sponsor work authorization/visas.
Additional Skills/Preferences:
- Mammalian cell culture expertise; extensive in vitro/ex vivo assay experience.
- Strong in vitro pharmacology/data analysis; ability to design/execute experimental plans on schedule.
- Cross-disciplinary collaboration; excellent written/verbal communication and interpersonal skills.
- Biologic modality experience (mAbs, ADCs, CD3-engaging platforms).
- Multiparameter flow cytometry (panel design and data analysis).
- Experience developing/validating bioanalytical assays; independent leadership of multiple research programs with minimal supervision.
- Managing external collaborations/CROs; presenting to technical and non-technical audiences.
- Knowledge/interest in cancer disease states.
Additional Information:
- Location: New York, NY. Travel: <10%.