Principal Scientist (Scientific Director Level)– Nonclinical Drug Safety

Role: Discovery Program Leader (DPL) specializing in Nonclinical Drug Safety (NDS) to guide discovery research in immunology and oncology. Primary objectives include defining and executing NDS strategies across modalities (small molecules, peptides, biologics, ADCs) from Target Identification to First-In-Human GLP toxicity studies; providing target risk assessments; and de-risking discovery programs. Responsibilities involve representing NDS in discovery teams, promoting innovative thinking across therapeutic areas, assessing target risks via literature and internal data, and potentially leading early development teams with focus on preclinical toxicology strategies and regulatory safety documentation. Requirements include a PhD, DVM, or MD, with 8+ years in industry as a non-clinical safety scientist or safety assessment representative, demonstrating leadership in cross-functional settings, and possessing excellent collaboration and communication skills. Preferred experience encompasses biopharmaceutical and small molecule development, regulatory submissions, and external scientific involvement. High-value specifics include emphasis on immunology and oncology, early to clinical development phases, GLP toxicology, safety assessment, and cross-site collaboration. Work setup is hybrid, based in the US with approximately 10% travel.