Principal Scientist (Scientific Director Level)– Nonclinical Drug Safety

Role: Discovery Program Leader (DPL) representing Nonclinical Drug Safety (NDS) in discovery research, primarily within immunology and oncology. Objectives include defining NDS strategy across modalities (small molecules, peptides, biologics, ADCs) from target ID to First-In-Human GLP toxicity studies, and supporting target risk assessments, de-risking, and safety evaluations. Responsibilities involve leading cross-functional discovery teams, promoting innovative thinking across therapeutic areas, assessing target-related risks, and potentially guiding early development activities, including non-clinical safety sections for regulatory submissions. Requirements: PhD, DVM, or MD; 8+ years in pharmaceutical non-clinical safety, toxicology, or related fields, with proven cross-functional influence and team leadership. Preferred skills include experience in biopharma discovery/development, regulatory submissions, and external scientific engagement. High-value specifics: focus on immunology and oncology therapeutic areas, involvement from discovery through GLP toxicity studies, and contribution to regulatory safety documentation. Work setup: hybrid (based in the US), with approximately 10% travel.