Principal Scientist, Research (Targeted Delivery)
Alnylam Pharmaceuticals
10 days ago
On-site
Cambridge, MA
Clinical Research and Development
Key Responsibilities:
- Lead design and implementation of innovative immunization strategies, including identifying, selecting, and managing external immunization vendors (CROs).
- Establish and oversee high-throughput B cell screening and selection workflows.
- Develop and integrate robust Next-Generation Sequencing (NGS) workflows to rapidly identify and analyze antibody variable region sequences from screening campaigns.
- Design, execute, and automate high-throughput screening cascades to characterize antibody properties (affinity, specificity, function).
- Engineer complex antibody modalities (multispecific antibodies, nanobodies) and evaluate novel protein formats.
- Collaborate with cross-functional teams (protein science, pharmacology, translational science) to achieve project goals.
- Manage project timelines, resources, and data analysis; present findings to internal teams and senior leadership.
Qualifications:
- PhD in Molecular Biology, Bioengineering, Biochemistry, Cell Biology, or related field.
- 6+ years post-PhD biopharmaceutical industry experience focused on antibody discovery and engineering.
- Proven track record leading antibody discovery programs from inception to lead candidate delivery.
- Hands-on single B cell isolation and screening; direct experience with Bruker Beacon platform required.
- Deep expertise in antibody cloning, expression, and sequence analysis; extensive experience with NGS library preparation and data interpretation.
- Experience developing and running high-throughput, automated screening assays.
- Experience managing external collaborations and CROs for immunization and discovery campaigns.
- Track record managing and developing research scientists (preferred).
Location/Work setup:
- Onsite; primarily located in Cambridge, MA.
Benefits:
- Medical, dental, and vision; life and disability insurance; lifestyle reimbursement; flexible spending/HSA; 401(k) with generous match; paid time off, wellness days, holidays, and two recharge breaks.
- Lead design and implementation of innovative immunization strategies, including identifying, selecting, and managing external immunization vendors (CROs).
- Establish and oversee high-throughput B cell screening and selection workflows.
- Develop and integrate robust Next-Generation Sequencing (NGS) workflows to rapidly identify and analyze antibody variable region sequences from screening campaigns.
- Design, execute, and automate high-throughput screening cascades to characterize antibody properties (affinity, specificity, function).
- Engineer complex antibody modalities (multispecific antibodies, nanobodies) and evaluate novel protein formats.
- Collaborate with cross-functional teams (protein science, pharmacology, translational science) to achieve project goals.
- Manage project timelines, resources, and data analysis; present findings to internal teams and senior leadership.
Qualifications:
- PhD in Molecular Biology, Bioengineering, Biochemistry, Cell Biology, or related field.
- 6+ years post-PhD biopharmaceutical industry experience focused on antibody discovery and engineering.
- Proven track record leading antibody discovery programs from inception to lead candidate delivery.
- Hands-on single B cell isolation and screening; direct experience with Bruker Beacon platform required.
- Deep expertise in antibody cloning, expression, and sequence analysis; extensive experience with NGS library preparation and data interpretation.
- Experience developing and running high-throughput, automated screening assays.
- Experience managing external collaborations and CROs for immunization and discovery campaigns.
- Track record managing and developing research scientists (preferred).
Location/Work setup:
- Onsite; primarily located in Cambridge, MA.
Benefits:
- Medical, dental, and vision; life and disability insurance; lifestyle reimbursement; flexible spending/HSA; 401(k) with generous match; paid time off, wellness days, holidays, and two recharge breaks.