Principal Scientist - Process Translation and Execution Lilly Medicine Foundry
Eli Lilly and Company
9 days ago
On-site
Lebanon, IN
Operations
Responsibilities:
- Facilitate transfer of chemical processes from development labs to pilot plant operations (kilo-/pilot-scale) to enable early-phase cGMP manufacturing of kilogram API for clinical trials.
- Operate and troubleshoot kilo-scale equipment (multi-purpose reactors, filtration systems, drying equipment incl. AFD and tray dryer).
- Apply chemical engineering principles for scale-up and equipment sizing.
- Develop/apply cake filtration models; design/execute filtration wash studies.
- Model/predict and control crystallization particle size distribution (PSD).
- Receive incoming process procedures and evaluate safety with chemist/safety group.
- Author/review SOPs, batch records, campaign summaries, and deviation reports.
- Perform Definitive Lab Trials and familiarization reactions for crystallization/filtration readiness.
- Order and stage GMP consumables/equipment parts; summarize/present results.
- Maintain lab notebooks; apply process improvement; support deviations, quality events, non-conformances; use a quality mindset.
Basic Requirements:
- BS or MS in Chemical Engineering (or closely related).
- 4+ years in pharmaceutical process development, pilot plant operations, or chemical manufacturing.
- Authorized to work in the U.S. (Lilly does not sponsor visas).
Additional Skills/Preferences:
- Hands-on kilo-/pilot-scale equipment experience.
- Experience with DeltaV, Dynochem, Aspen, and/or electronic lab notebooks.
- Crystallization development (polymorph control, nucleation/growth kinetics, seeding, PSD).
- Filtration modeling; FDA/cGMP knowledge; strong data/reasoning and communication; cross-functional collaboration.
Other Information (Role):
- Initial location: Parkwood West and Lilly Technology Center, Indianapolis; permanent: Lilly Medicine Foundry, Lebanon, IN. Travel <5%. Manufacturing/lab environment; possible nights/weekends.
Compensation/Benefits (if applicable):
- Anticipated wage: $66,000–$171,600; may be eligible for company bonus and comprehensive benefits (incl. 401(k), medical/dental/vision, life insurance, time off).
- Facilitate transfer of chemical processes from development labs to pilot plant operations (kilo-/pilot-scale) to enable early-phase cGMP manufacturing of kilogram API for clinical trials.
- Operate and troubleshoot kilo-scale equipment (multi-purpose reactors, filtration systems, drying equipment incl. AFD and tray dryer).
- Apply chemical engineering principles for scale-up and equipment sizing.
- Develop/apply cake filtration models; design/execute filtration wash studies.
- Model/predict and control crystallization particle size distribution (PSD).
- Receive incoming process procedures and evaluate safety with chemist/safety group.
- Author/review SOPs, batch records, campaign summaries, and deviation reports.
- Perform Definitive Lab Trials and familiarization reactions for crystallization/filtration readiness.
- Order and stage GMP consumables/equipment parts; summarize/present results.
- Maintain lab notebooks; apply process improvement; support deviations, quality events, non-conformances; use a quality mindset.
Basic Requirements:
- BS or MS in Chemical Engineering (or closely related).
- 4+ years in pharmaceutical process development, pilot plant operations, or chemical manufacturing.
- Authorized to work in the U.S. (Lilly does not sponsor visas).
Additional Skills/Preferences:
- Hands-on kilo-/pilot-scale equipment experience.
- Experience with DeltaV, Dynochem, Aspen, and/or electronic lab notebooks.
- Crystallization development (polymorph control, nucleation/growth kinetics, seeding, PSD).
- Filtration modeling; FDA/cGMP knowledge; strong data/reasoning and communication; cross-functional collaboration.
Other Information (Role):
- Initial location: Parkwood West and Lilly Technology Center, Indianapolis; permanent: Lilly Medicine Foundry, Lebanon, IN. Travel <5%. Manufacturing/lab environment; possible nights/weekends.
Compensation/Benefits (if applicable):
- Anticipated wage: $66,000–$171,600; may be eligible for company bonus and comprehensive benefits (incl. 401(k), medical/dental/vision, life insurance, time off).