Principal Scientist - Process Translation and Execution Lilly Medicine Foundry
Eli Lilly and Company
August 23, 2026
On-site
Lebanon, IN
Operations
Responsibilities:
- Facilitate transfer of chemical processes (under supervisory guidance) from development labs to pilot plant operations (kilo/pilot-scale) to enable early-phase cGMP manufacturing of kilogram quantities of API for clinical trials.
- Operate/troubleshoot kilo-scale equipment (multi-purpose reactors, filtration systems, drying equipment incl. AFD and tray dryers).
- Apply chemical engineering principles to scale-up and equipment sizing (heat/mass transfer, kinetics, thermodynamics, fluid dynamics).
- Develop/apply cake filtration models; design/execute filtration wash studies.
- Model or use semi-empirical approaches to predict/control crystallization particle size distribution (PSD).
- Evaluate incoming procedures’ safety with chemist/safety group; execute documentation (SOPs, batch records, campaign summaries, deviations).
- Perform/Document Definitive Lab Trials and familiarization reactions for crystallization/filtration readiness.
- Order/stage GMP consumables and parts for kilolab runs; summarize/present results.
- Maintain detailed lab notebooks; apply process improvement; support deviations, quality events, and non-conformances; use a quality mindset.
Qualifications (Basic Requirements):
- BS or MS in Chemical Engineering (or closely related).
- 4+ years industry experience in pharmaceutical process development, pilot plant operations, or chemical manufacturing.
- Authorized to work in the U.S. full-time; no visa sponsorship.
Additional Skills/Preferences:
- Hands-on kilo/pilot-scale experience; filtration/crystallization expertise (polymorph control, nucleation/growth, seeding, PSD).
- Software: DeltaV, Dynochem, Aspen, and/or electronic lab notebooks.
- FDA/cGMP knowledge; ability to manage ambiguity; strong communication, data analysis/root-cause, cross-functional collaboration.
Compensation/Benefits (as stated):
- Anticipated wage: $66,000–$171,600. Potential company bonus; comprehensive benefits (e.g., 401(k), medical/dental/vision, flexible benefits, life insurance, time off, well-being).
- Facilitate transfer of chemical processes (under supervisory guidance) from development labs to pilot plant operations (kilo/pilot-scale) to enable early-phase cGMP manufacturing of kilogram quantities of API for clinical trials.
- Operate/troubleshoot kilo-scale equipment (multi-purpose reactors, filtration systems, drying equipment incl. AFD and tray dryers).
- Apply chemical engineering principles to scale-up and equipment sizing (heat/mass transfer, kinetics, thermodynamics, fluid dynamics).
- Develop/apply cake filtration models; design/execute filtration wash studies.
- Model or use semi-empirical approaches to predict/control crystallization particle size distribution (PSD).
- Evaluate incoming procedures’ safety with chemist/safety group; execute documentation (SOPs, batch records, campaign summaries, deviations).
- Perform/Document Definitive Lab Trials and familiarization reactions for crystallization/filtration readiness.
- Order/stage GMP consumables and parts for kilolab runs; summarize/present results.
- Maintain detailed lab notebooks; apply process improvement; support deviations, quality events, and non-conformances; use a quality mindset.
Qualifications (Basic Requirements):
- BS or MS in Chemical Engineering (or closely related).
- 4+ years industry experience in pharmaceutical process development, pilot plant operations, or chemical manufacturing.
- Authorized to work in the U.S. full-time; no visa sponsorship.
Additional Skills/Preferences:
- Hands-on kilo/pilot-scale experience; filtration/crystallization expertise (polymorph control, nucleation/growth, seeding, PSD).
- Software: DeltaV, Dynochem, Aspen, and/or electronic lab notebooks.
- FDA/cGMP knowledge; ability to manage ambiguity; strong communication, data analysis/root-cause, cross-functional collaboration.
Compensation/Benefits (as stated):
- Anticipated wage: $66,000–$171,600. Potential company bonus; comprehensive benefits (e.g., 401(k), medical/dental/vision, flexible benefits, life insurance, time off, well-being).