Principal Scientist, Oligonucleotide (PMO, ASO) Development

Role: Principal Scientist of Oligonucleotide Development leading chemical synthesis strategy for PMO and modified ASO payloads, overseeing preclinical process, analytical development, and GMP manufacturing for IND-enabling studies. Responsibilities include process design and optimization, analytical strategy development, external CDMO management, technology transfer, and supporting regulatory filings (IND, IMPD). Requirements: Bachelor's in Chemistry, Chemical Engineering, or related; 8+ years in biotech/pharma with expertise in oligonucleotide process chemistry, synthesis, purification, and analytical characterization; experience managing CDMOs; strong cross-functional collaboration skills. HighValue: Focus on oligonucleotide therapeutics (PMO, ASO), early-stage development, GMP manufacturing, regulatory documentation, and process optimization within a clinical-stage biotech environment. Work setup: onsite in Waltham, MA, 4-5 days/week.