Principal Scientist β Multiscale Separations Team Lead
Merck
October 1, 2026
Full-time
On-site
Rahway, NJ
Clinical Research and Development
Role: Principal Scientist leading Separation Sciences within Analytical Enabling Capabilities in Rahway, NJ, supporting drug development across modalities including small molecules, biologics, peptides, and ADCs. Responsibilities: provide scientific leadership in chromatography and purification workflows (HPLC, SFC, LCMS), support structure-activity and impurity studies, develop innovative technologies and workflows, mentor staff, and collaborate cross-functionally with process chemistry, analytical sciences, automation, informatics, and external vendors. Requirements: Ph.D. in Chemistry, Analytical Chemistry, Pharmaceutical Sciences, or Chemical Engineering with 8+ years of industry experience supporting pharmaceutical R&D; expertise in chromatography, purification, and analytical separation techniques; experience with multiple modalities, scale-up, and cGMP is preferred. HighValue: deep technical expertise in HPLC/SFC, support for diverse modalities (small molecules, peptides, ADCs), hands-on experience from microgram to kilogram scale, implementation of digital and automation solutions, and external scientific engagement. WorkSetup: on-site in Rahway with 10% travel.