Principal Scientist, Molecular Genomics
Bristol Myers Squibb
August 17, 2026
Remote friendly (Princeton, NJ)
United States
Clinical Research and Development
Key Responsibilities:
- Lead development and implementation of genomics and transcriptomics biomarker strategies for translational medicine and clinical programs.
- Select/evaluate PCR and NGS-based assay technologies (GEP, genotyping, variant analysis, ctDNA) to meet program/protocol/biological needs.
- Design, develop, optimize, qualify, validate, and execute biomarker assays; support pharmacodynamic/target engagement/predictive/prognostic assays and platform development.
- Create qualification/validation plans, protocols, reports, SOPs and technical documentation; generate/analyze qualification datasets for fit-for-purpose deployment.
- Perform hands-on laboratory work (PCR, qPCR, NGS, gene expression, genotyping, variant analysis); troubleshoot, implement corrective actions, and ensure robustness/reproducibility.
- Oversee internal and vendor-based clinical sample analysis; review QC metrics and performance trends; serve as SME on genomics technologies and biomarker strategies.
- Evaluate emerging technologies, run due diligence/pilot studies, lead technology transfer, collaborate cross-functionally, maintain compliant records, and mentor junior scientists.
Qualifications:
- BS (8+ yrs) or MS (6+ yrs) or PhD (4+ yrs) in Life Sciences (or related).
- 100% lab environment availability.
- Extensive hands-on experience with PCR/qPCR/NGS, GEP, genomics-based technologies; strong assay development/optimization/qualification/validation/troubleshooting/lifecycle management.
- Proven experience developing clinical genomics assays; oversight of vendor validation; strong QC/controls understanding.
- Expertise with NGS/qPCR, gene expression profiling, genotyping, variant analysis; ctDNA and fit-for-purpose validation principles.
- Knowledge of genomics data structures/quality control; collaboration with bioinformatics/biostatistics.
- Strong organizational, communication, cross-functional/matrix leadership, and mentoring skills.
Benefits (as stated):
- Medical/pharmacy/dental/vision; wellbeing programs; 401(k), disability, life/accident/supplemental insurance, travel and liability protection.
- Paid time off (flexible time off or annual vacation per eligibility) plus national holidays.
Application instruction:
- If you’re interested but don’t perfectly match, apply anyway.
- Lead development and implementation of genomics and transcriptomics biomarker strategies for translational medicine and clinical programs.
- Select/evaluate PCR and NGS-based assay technologies (GEP, genotyping, variant analysis, ctDNA) to meet program/protocol/biological needs.
- Design, develop, optimize, qualify, validate, and execute biomarker assays; support pharmacodynamic/target engagement/predictive/prognostic assays and platform development.
- Create qualification/validation plans, protocols, reports, SOPs and technical documentation; generate/analyze qualification datasets for fit-for-purpose deployment.
- Perform hands-on laboratory work (PCR, qPCR, NGS, gene expression, genotyping, variant analysis); troubleshoot, implement corrective actions, and ensure robustness/reproducibility.
- Oversee internal and vendor-based clinical sample analysis; review QC metrics and performance trends; serve as SME on genomics technologies and biomarker strategies.
- Evaluate emerging technologies, run due diligence/pilot studies, lead technology transfer, collaborate cross-functionally, maintain compliant records, and mentor junior scientists.
Qualifications:
- BS (8+ yrs) or MS (6+ yrs) or PhD (4+ yrs) in Life Sciences (or related).
- 100% lab environment availability.
- Extensive hands-on experience with PCR/qPCR/NGS, GEP, genomics-based technologies; strong assay development/optimization/qualification/validation/troubleshooting/lifecycle management.
- Proven experience developing clinical genomics assays; oversight of vendor validation; strong QC/controls understanding.
- Expertise with NGS/qPCR, gene expression profiling, genotyping, variant analysis; ctDNA and fit-for-purpose validation principles.
- Knowledge of genomics data structures/quality control; collaboration with bioinformatics/biostatistics.
- Strong organizational, communication, cross-functional/matrix leadership, and mentoring skills.
Benefits (as stated):
- Medical/pharmacy/dental/vision; wellbeing programs; 401(k), disability, life/accident/supplemental insurance, travel and liability protection.
- Paid time off (flexible time off or annual vacation per eligibility) plus national holidays.
Application instruction:
- If you’re interested but don’t perfectly match, apply anyway.