Principal Scientist, Metabolomics

Role Summary

Principal Scientist, Metabolomics. The role focuses on metabolomics and bioanalytical LC-MS to advance drug discovery programs, collaborating with global experts in proteomics, metabolomics, lipidomics, and data science. Located onsite in Cambridge, MA, with opportunities to influence technologies and methodologies across multiple disease areas.

Responsibilities

• Collaborate with project partners to design and execute analytical studies that address key scientific questions for the drug discovery program.
• Lead and participate in high-impact lipidomics and metabolomics projects within drug discovery, spanning from early research to patient translation.
• Champion innovative technologies and cross-disciplinary initiatives to augment the group's technology portfolio and capabilities.
• Develop and optimize tools for understanding metabolism and transport, identify disease-associated lipid markers, and study metabolic flux to enable next-generation therapies.
• Maintain a state-of-the-art lipidomics and metabolomics technology platform by staying current with external developments and aligning with internal project priorities.
• Execute all aspects of analytical studies including sample preparation, LC-MS analysis, data processing, and analysis.
• Document work using internal documentation systems and present key outcomes to project teams with follow-up steps.
• Develop and implement new LC-MS methods based on project needs.
• Contribute to assessing and implementing state-of-the-art analytical methodologies to elucidate metabolism in diseases and responses to therapeutics.

Qualifications

• Ph.D. in analytical chemistry, biochemistry, or related field with a minimum of 2+ years postdoctoral experience; or MS/BS with 10+ years of pharma/biotech experience.
• Expertise in biological mass spectrometry and metabolomics, including quantitative targeted/multi-targeted LC-MS analyses of endogenous small molecules (metabolites and lipids) and metabolic profiling from complex matrices.
• Experience with sample preparation and extraction protocols from various cell types, tissues, and biofluids for MS analysis of endogenous small molecules.
• Proven ability to document experiments and results in electronic lab notebooks or LIMS.
• Strong problem-solving skills, independent thinking, and excellent communication and presentation skills for multidisciplinary audiences.
• Excellent interpersonal skills for collaboration in a matrix environment and the ability to share results across teams.

Skills

• Mass spectrometry
• Lipidomics and metabolomics
• LC-MS method development
• Metabolic pathway analysis
• Data processing and interpretation

Education

• Ph.D. in analytical chemistry, biochemistry, or related field; or equivalent combination of education and experience as detailed in qualifications.

Additional Requirements

• Location: onsite, Cambridge, MA