Principal Scientist, Metabolomics

Role Summary

We are looking for an enthusiastic, curious, and highly motivated individual with experience in metabolomics and bioanalytical LC-MS to join our Translational Profiling group within the Discovery Sciences department in Cambridge, MA. Our Translational Profiling group is a global team of experts in proteomics, metabolomics, lipidomics, super-resolution microscopy, and data science, with locations in Basel, Switzerland, and Cambridge, MA.

Responsibilities

• Collaborate with project partners to design and execute analytical studies that will address the key scientific question experiments of that drug discovery program.
• Lead and participate in high impact lipidomics and metabolomics projects within drug discovery programs, spanning from early research to patient translation.
• Championing innovative technology and cross-disciplinary initiatives for biomedical research, including state-of-the-art analytical methodologies to augment the group’s technology portfolio and capabilities
• Developing and optimizing tools for understanding metabolism and transport, identify disease-associated lipid markers, studying metabolic flux to enable next-generation therapies for patients.
• Maintain a state-of-the-art lipidomics and metabolomics technology platform by staying current with external technology developments and aligning with internal project requirements and application priorities.
• Execute all aspects of an analytical study including sample preparation, LC-MS analysis, to data processing and analysis.
• Document your work using our internal documentation system.
• Present the key outcomes of experiments to the project team and plan follow-up steps to further advance the project.
• Develop and implement new LC-MS methods based on project needs.
• Contribute to the assessing and implementing state-of-the-art analytical methodologies to augment the group’s technology portfolio and expand its abilities to elucidate the role of metabolism in diseases and the response to therapeutics.

Qualifications

• A Ph.D. in analytical chemistry, biochemistry, or related field with a minimum of 2+ years of postgraduate experience, Or an MS or BS degree with 10+ years’ experience in pharma/biotech.
• Expertise in biological mass spectrometry and metabolomics including but not limited to the following key areas: quantitative targeted/multi-targeted LC-MS analyses of endogenous small molecules, i.e., metabolites and lipids; metabolic profiling of samples originating from complex biological matrices, such as cell culture, biofluids, and organ tissues.
• Expertise in sample preparation and extraction protocols from different cell types, tissues and biofluids of animal or human origin to generate material for mass spectrometric analysis of endogenous small molecules.
• Demonstrated diligence documenting experiments, data and results in electronic lab journal or laboratory information management systems.
• Critical and creative problem-solving skills with independent thinking.
• Excellent communication and presentation skills for multidisciplinary audiences across various seniority and expertise levels.
• Excellent interpersonal skills to work in a collaborative, matrix environment, fostering partnerships across functional teams. You are curious, readily speak up and share results within and beyond project teams, acting as inspirational role model to others.

Skills

• Mass spectrometry
• Lipidomics and metabolomics
• LC-MS method development
• Analytical chemistry
• Data processing and interpretation

Education

• Ph.D. in analytical chemistry, biochemistry, or related field (preferred) or corresponding extensive industry experience as outlined above.