Principal Scientist Metabolism Bioscience Research, CVRM

Role Summary

Are you an expert in skeletal muscle biology? Join us to accelerate innovative science and turn ideas into life-changing medicines, focusing on Cardiovascular, Renal and Metabolic (CVRM) diseases. We are seeking a Principal Scientist with expertise in skeletal muscle physiology, metabolism and drug discovery to join the Metabolism Bioscience Team within Research and Early Development CVRM. This role shapes strategy for obesity and weight management and leads to discovery through early clinical development.

Responsibilities

• Apply expertise in skeletal muscle physiology and metabolic diseases to drive scientific and technical innovation, advancing new therapeutic interventions.
• Lead multidisciplinary global project teams, as well as external collaborators, to deliver key experimental data and progress the drug project portfolio.
• Champion novel approaches to drug discovery in healthy weight loss and body weight maintenance, facilitating scientific debate and innovation through leadership and mentorship within the CVRM Research community.
• Contribute to the evolution of research strategy within the Metabolism Bioscience division as a member of its leadership team.
• Play a lead role in the selection and validation of research targets, taking projects from discovery through to early clinical development, and serve as bioscience lead on discovery projects.
• Raise the scientific profile of CVRM both internally and externally through high-impact publications, conference presentations, and collaborative initiatives.
• Report directly to the Senior Director of Metabolism Bioscience.

Qualifications

• Required: PhD and postdoctoral experience in life sciences or equivalent relevant industry experience.
• Required: 5+ years‚Äô drug discovery experience in academia, biotech, or pharmaceutical industry following postdoctoral research.
• Required: Deep expertise in skeletal muscle biology and physiology, including in vitro and in vivo assay development.
• Required: Extensive scientific knowledge of metabolic diseases and mechanisms of body weight regulation, with a strong track record of leading laboratory-based research.
• Required: Experience in new model development, laboratory techniques, and hands-on science.
• Required: Demonstrated scientific leadership evidenced by publications, external presentations, and collaborations.
• Required: Proven ability to manage multifaceted projects and establish research collaborations, leveraging a broad professional network.
• Required: Track record as a project leader or bioscience lead, conducting and guiding complex scientific projects within multidisciplinary teams.
• Preferred: Significant experience with in vitro, in vivo, and ex vivo technologies to assess multiple target classes.
• Preferred: Ability to manage multiple concurrent projects or tasks.
• Preferred: Extensive network and collaboration experience within the obesity metabolism research field.

Skills

• Skeletal muscle physiology and metabolism
• In vitro, in vivo, and ex vivo assay development
• Drug discovery leadership and project management
• Scientific publishing, presentations, and external collaborations
• Strategic planning and leadership within multidisciplinary teams