Principal Scientist, Integrated Computational and Experimental Inflammation Discovery
Amgen
August 14, 2026
Remote friendly (South San Francisco, CA)
United States
Clinical Research and Development
Principal Scientist, Integrated Computational and Experimental Inflammation Discovery
What You Will Do
Combine experimental and computational strategies to accelerate discovery and development of innovative therapies. Apply wet-lab biology expertise and AI/ML-driven computational and agentic research approaches to enable human-data-driven understanding of disease mechanisms and therapeutic opportunities.
Key Responsibilities
- Continuously apply computational, agentic, and other AI-driven approaches to generate mechanistic insights, refine therapeutic hypotheses, and guide experimental design.
- Design, execute, analyze, and interpret studies to investigate disease mechanisms and test therapeutic hypotheses.
- Generate high-quality experimental data to support target identification, validation, and progression of Inflammation research programs.
- Integrate experimental findings with published literature, human genetics, clinical observations, and other data sources to develop mechanistic insights and inform scientific decision-making.
- Participate in scientific discussions, target reviews, and portfolio evaluations with data-driven insights and recommendations.
- Present findings and recommendations to project teams and governance/forums.
- Maintain accurate documentation and contribute to knowledge-sharing.
- Embrace and contribute to a culture of scientific curiosity, collaboration, continuous learning, and operational excellence.
Basic Qualifications
- PhD
OR PharmD
OR MD (and relevant post-doc where applicable) with 2 years industry experience in Inflammation/Immunology
OR Master’s with 5 years industry experience in Inflammation/Immunology
OR Bachelor’s with 7 years industry experience in Inflammation/Immunology
Preferred Qualifications
- Experience in highly collaborative, matrixed research environments.
- Ability to balance scientific rigor with urgency and adaptability.
- Commitment to teamwork, knowledge sharing, and continuous improvement.
Application instructions
- Apply via careers.amgen.com. Application acceptance anticipated until July 31 (may continue beyond if needed).
What You Will Do
Combine experimental and computational strategies to accelerate discovery and development of innovative therapies. Apply wet-lab biology expertise and AI/ML-driven computational and agentic research approaches to enable human-data-driven understanding of disease mechanisms and therapeutic opportunities.
Key Responsibilities
- Continuously apply computational, agentic, and other AI-driven approaches to generate mechanistic insights, refine therapeutic hypotheses, and guide experimental design.
- Design, execute, analyze, and interpret studies to investigate disease mechanisms and test therapeutic hypotheses.
- Generate high-quality experimental data to support target identification, validation, and progression of Inflammation research programs.
- Integrate experimental findings with published literature, human genetics, clinical observations, and other data sources to develop mechanistic insights and inform scientific decision-making.
- Participate in scientific discussions, target reviews, and portfolio evaluations with data-driven insights and recommendations.
- Present findings and recommendations to project teams and governance/forums.
- Maintain accurate documentation and contribute to knowledge-sharing.
- Embrace and contribute to a culture of scientific curiosity, collaboration, continuous learning, and operational excellence.
Basic Qualifications
- PhD
OR PharmD
OR MD (and relevant post-doc where applicable) with 2 years industry experience in Inflammation/Immunology
OR Master’s with 5 years industry experience in Inflammation/Immunology
OR Bachelor’s with 7 years industry experience in Inflammation/Immunology
Preferred Qualifications
- Experience in highly collaborative, matrixed research environments.
- Ability to balance scientific rigor with urgency and adaptability.
- Commitment to teamwork, knowledge sharing, and continuous improvement.
Application instructions
- Apply via careers.amgen.com. Application acceptance anticipated until July 31 (may continue beyond if needed).