Principal Scientist, Inflammation
Amgen
August 07, 2026
Remote friendly (South San Francisco, CA)
United States
Clinical Research and Development
Principal Scientist, Inflammation
What You Will Do
Lead discovery and translational biology for a novel immune-targeting therapeutic platform focused on selective modulation of pathogenic immune-cell populations in autoimmune and inflammatory diseases.
Key Responsibilities
- Lead in vitro and ex vivo biological strategy for immune-targeting platform; evaluate immune effector activity and target cell elimination.
- Design and execute in vivo studies assessing lymphocyte-mediated target cell depletion, immune pharmacology, and durability of responses in mouse models.
- Develop/optimize in vitro and ex vivo functional immune-cell assays (co-culture systems; cytotoxicity/target-cell modulation; readouts for activation, expansion, persistence, target engagement, pharmacodynamics).
- Build translational capabilities: immune profiling, biodistribution, pharmacodynamic biomarker development.
- Integrate in vitro/in vivo data for mechanistic insights to guide optimization and candidate selection.
- Advance candidates via preclinical efficacy and mechanistic datasets.
- Collaborate across discovery biology, protein engineering, delivery sciences, in vivo pharmacology, and translational safety; perform/analyze experiments (in vitro/ex vivo/in silico/in vivo).
- Contribute on cross-functional teams: synthesize data, document results, present recommendations.
Basic Qualifications
- PhD, or PharmD, or MD (with relevant post-doc where applicable) + 2 years drug discovery/academic; OR MS + 5 years; OR BS + 7 years.
Preferred Qualifications
- PhD with deep lymphocyte biology/immune effector expertise + 5+ years immunology research; publications in high-impact journals.
- Strong in vitro/ex vivo immunology, primary immune-cell assays, co-cultures, cytotoxicity/target depletion assays, high-parameter flow; desirable: activation states/effector function/persistence/target engagement/pk–pd; mouse model experience; familiarity with small/large molecule discovery, MOA, ELISA/MSD, flow profiling, scRNA-Seq, CRISPR/Cas9, omics.
Application Instructions
Apply now.
Benefits (if eligible)
- Comprehensive employee benefits, including retirement/savings, medical/dental/vision, life/disability, flexible spending; bonus; stock-based long-term incentives; time-off; flexible work models where possible.
What You Will Do
Lead discovery and translational biology for a novel immune-targeting therapeutic platform focused on selective modulation of pathogenic immune-cell populations in autoimmune and inflammatory diseases.
Key Responsibilities
- Lead in vitro and ex vivo biological strategy for immune-targeting platform; evaluate immune effector activity and target cell elimination.
- Design and execute in vivo studies assessing lymphocyte-mediated target cell depletion, immune pharmacology, and durability of responses in mouse models.
- Develop/optimize in vitro and ex vivo functional immune-cell assays (co-culture systems; cytotoxicity/target-cell modulation; readouts for activation, expansion, persistence, target engagement, pharmacodynamics).
- Build translational capabilities: immune profiling, biodistribution, pharmacodynamic biomarker development.
- Integrate in vitro/in vivo data for mechanistic insights to guide optimization and candidate selection.
- Advance candidates via preclinical efficacy and mechanistic datasets.
- Collaborate across discovery biology, protein engineering, delivery sciences, in vivo pharmacology, and translational safety; perform/analyze experiments (in vitro/ex vivo/in silico/in vivo).
- Contribute on cross-functional teams: synthesize data, document results, present recommendations.
Basic Qualifications
- PhD, or PharmD, or MD (with relevant post-doc where applicable) + 2 years drug discovery/academic; OR MS + 5 years; OR BS + 7 years.
Preferred Qualifications
- PhD with deep lymphocyte biology/immune effector expertise + 5+ years immunology research; publications in high-impact journals.
- Strong in vitro/ex vivo immunology, primary immune-cell assays, co-cultures, cytotoxicity/target depletion assays, high-parameter flow; desirable: activation states/effector function/persistence/target engagement/pk–pd; mouse model experience; familiarity with small/large molecule discovery, MOA, ELISA/MSD, flow profiling, scRNA-Seq, CRISPR/Cas9, omics.
Application Instructions
Apply now.
Benefits (if eligible)
- Comprehensive employee benefits, including retirement/savings, medical/dental/vision, life/disability, flexible spending; bonus; stock-based long-term incentives; time-off; flexible work models where possible.