Principal Scientist, Inflammation
Amgen
August 28, 2026
Full-time
Remote friendly (South San Francisco, CA)
Worldwide
Clinical Research and Development
Role: Lead discovery and translational biology efforts for a novel immune-targeting platform in autoimmune and inflammatory diseases, focusing on immune cell modulation and target validation. Responsibilities: design and execute in vitro, ex vivo, and in vivo immune assays, develop immune profiling and biomarker strategies, analyze mechanistic data, and support candidate advancement toward development. Collaborate cross-functionally with biology, protein engineering, pharmacology, and safety teams; present findings to internal and external audiences. Qualifications: PhD in immunology, lymphocyte biology, or related field with 5+ years of research experience in industry or academia, including expertise in immune effector mechanisms, cell assays, flow cytometry, and preclinical models. Preferred skills include high-impact publications, experience with immune-mediated target modulation in mouse models, and familiarity with omics and gene editing techniques. High-value specifics: focus on immune modulation in autoimmune/inflammatory diseases, immune cell profiling, preclinical pharmacology, and translational research platforms. Work setup: not specified, but likely collaborative and research-focused.