Principal Scientist In Vivo Immunology
GSK
2 months ago
On-site
Cambridge, MA
Clinical Research and Development
Job Purpose:
- Principal Scientist in the in vivo immunology team; serve as preclinical in vivo study lead and represent the project team to spearhead innovation of novel viral vaccines and platform programs.
- Lead in vivo efforts on multiple viral vaccine programs and platforms within GSK and with external partners; design and write in vivo study protocols; coordinate and initiate preclinical studies; conduct and analyze experimental results to understand immune responses from novel vaccine candidates, formulations, and platforms.
Key Responsibilities:
- Design, plan, conduct, coordinate, monitor, and analyze in vivo murine studies for vaccine and platform programs (may serve as preclinical in vivo lead).
- Ensure compliance with Institutional Animal Care and Use Committee (IACUC) guidelines by writing/reviewing in vivo study protocols and participating in the independent scientific review committee.
- Conduct dosing, IVIS imaging, necropsy, and tissue harvest from animal studies; supervise technicians.
- Perform experiments characterizing cell-mediated immune responses for preclinical immunogenicity or challenge studies using flow cytometry, ELISPOT, Luminex, MSD assays, and others.
- Support identification of novel vaccine candidates and platform development as a preclinical in vivo study lead in a matrix team.
- Prepare and document study protocols and final reports as an author.
- Contribute to patent filing, Investigational New Drug (IND) submissions, and scientific publications.
- Present study plans and results at project meetings.
- Develop new experimental techniques based on project needs.
- Mentor and train junior scientists.
Basic Qualifications (Required):
- Ph.D. or M.S. degree in immunology or related field.
- 4+ years post-Ph.D. or 6+ years post-M.S. experience in immunology or related field.
- Experience conducting in vivo animal studies (vaccines, infectious diseases, or immunology).
- Experience with small rodent handling and drug administration; in-study blood sampling, necropsy, tissue harvest, and processing.
- Experience designing, executing, and analyzing immune response readouts using conventional or spectral flow cytometry.
Preferred Qualifications:
- Matrix management experience; collaborative team player with strong interpersonal skills.
- Detail-oriented; able to balance multiple projects.
- Highly organized with experience documenting study protocols and reports.
- Experience with ELISPOT, Luminex, and qPCR methodologies.
- Experience preparing and delivering written and verbal communications professionally.
Benefits (explicitly mentioned):
- Annual bonus.
- Eligibility to participate in share-based long-term incentive program.
- Health care and other insurance benefits, retirement benefits, paid holidays, vacation, and paid caregiver/parental and medical leave.
Compensation (explicitly mentioned for specific locations):
- Annual base salary range (Cambridge, MA; Waltham, MA; Rockville, MD; or San Francisco, CA): $115,500 to $192,500.
- Principal Scientist in the in vivo immunology team; serve as preclinical in vivo study lead and represent the project team to spearhead innovation of novel viral vaccines and platform programs.
- Lead in vivo efforts on multiple viral vaccine programs and platforms within GSK and with external partners; design and write in vivo study protocols; coordinate and initiate preclinical studies; conduct and analyze experimental results to understand immune responses from novel vaccine candidates, formulations, and platforms.
Key Responsibilities:
- Design, plan, conduct, coordinate, monitor, and analyze in vivo murine studies for vaccine and platform programs (may serve as preclinical in vivo lead).
- Ensure compliance with Institutional Animal Care and Use Committee (IACUC) guidelines by writing/reviewing in vivo study protocols and participating in the independent scientific review committee.
- Conduct dosing, IVIS imaging, necropsy, and tissue harvest from animal studies; supervise technicians.
- Perform experiments characterizing cell-mediated immune responses for preclinical immunogenicity or challenge studies using flow cytometry, ELISPOT, Luminex, MSD assays, and others.
- Support identification of novel vaccine candidates and platform development as a preclinical in vivo study lead in a matrix team.
- Prepare and document study protocols and final reports as an author.
- Contribute to patent filing, Investigational New Drug (IND) submissions, and scientific publications.
- Present study plans and results at project meetings.
- Develop new experimental techniques based on project needs.
- Mentor and train junior scientists.
Basic Qualifications (Required):
- Ph.D. or M.S. degree in immunology or related field.
- 4+ years post-Ph.D. or 6+ years post-M.S. experience in immunology or related field.
- Experience conducting in vivo animal studies (vaccines, infectious diseases, or immunology).
- Experience with small rodent handling and drug administration; in-study blood sampling, necropsy, tissue harvest, and processing.
- Experience designing, executing, and analyzing immune response readouts using conventional or spectral flow cytometry.
Preferred Qualifications:
- Matrix management experience; collaborative team player with strong interpersonal skills.
- Detail-oriented; able to balance multiple projects.
- Highly organized with experience documenting study protocols and reports.
- Experience with ELISPOT, Luminex, and qPCR methodologies.
- Experience preparing and delivering written and verbal communications professionally.
Benefits (explicitly mentioned):
- Annual bonus.
- Eligibility to participate in share-based long-term incentive program.
- Health care and other insurance benefits, retirement benefits, paid holidays, vacation, and paid caregiver/parental and medical leave.
Compensation (explicitly mentioned for specific locations):
- Annual base salary range (Cambridge, MA; Waltham, MA; Rockville, MD; or San Francisco, CA): $115,500 to $192,500.