Principal Scientist, In Vitro Pharmacology
Pfizer
2 months ago
On-site
Cambridge, MA
Clinical Research and Development
In this role, you will:
- Develop assays for in vitro screening using binding, signaling and functional endpoints; support low to medium throughput screening.
- Validate in vitro cell models using immortalized, primary cells, and co-culture systems; adapt to cell-based screening assays at required throughput.
- Independently conceptualize, design and conduct in vitro studies to dissect molecular pharmacology of emerging therapeutic modulators targeting GPCRs, enzymes, and other protein classes.
- Apply rigorous data analytical methods to ensure robust scientific interpretation.
- Translate experimental results to advance understanding of target biology and define how physiological endpoints are impacted by pharmacological agents.
- Facilitate and co-author manuscript submissions and publication to high-impact peer-reviewed journals.
- Stay current on cutting-edge scientific/technical developments in preclinical to clinical translation and apply them to advance portfolio programs.
- Ensure research/discovery work follows highest quality standards, ethical guidelines, and relevant regulatory, QC, and compliance guidelines.
Here is what you need (Minimum Requirements):
- BA/BS and 12 years, or MS and 9 years, or PhD and 4 years of relevant experience in biochemistry, cell biology and/or pharmacology. Industry and cardiometabolic experience are a plus.
- Experience supporting in vitro screening in a drug discovery environment with GPCR, enzyme, and other target protein classes; strong plate-based pharmacology background. Lab automation experience is a plus.
- Experience with Mechanism of Action (MoA) or molecular pharmacology, including hands-on traditional and novel screening methodologies; concepts related to GPCR/enzyme drug discovery, signaling and trafficking.
- Background on cell-based assay development and extensive mammalian cell culture experience.
- Scientific rigor; ability to critically review data and independently/creatively formulate and test hypotheses.
- Excellent communication and interpersonal skills; ability to work independently and in an interdisciplinary team.
- Strong scientific writing skills with publications in high-impact pharmacology journals and presentations at international conferences.
- Ability to mentor junior colleagues both technically and scientifically.
Physical/Mental Requirements:
- Ability to perform laboratory bench work and tissue culture; lifting, sitting, standing, walking, bending; mathematical calculations; complex data analysis.
Relocation support: Available.
Work Location Assignment: On Premise.
Compensation/benefits (if applicable):
- Annual base salary range: $106,000.00 to $176,600.00.
- Eligible for Global Performance Plan bonus target of 15.0% of base salary and share-based long term incentive program.
- 401(k) with Pfizer Matching Contributions; additional retirement savings contribution; paid vacation/holidays/personal days; paid caregiver/parental and medical leave; medical/prescription/dental/vision coverage.
- Develop assays for in vitro screening using binding, signaling and functional endpoints; support low to medium throughput screening.
- Validate in vitro cell models using immortalized, primary cells, and co-culture systems; adapt to cell-based screening assays at required throughput.
- Independently conceptualize, design and conduct in vitro studies to dissect molecular pharmacology of emerging therapeutic modulators targeting GPCRs, enzymes, and other protein classes.
- Apply rigorous data analytical methods to ensure robust scientific interpretation.
- Translate experimental results to advance understanding of target biology and define how physiological endpoints are impacted by pharmacological agents.
- Facilitate and co-author manuscript submissions and publication to high-impact peer-reviewed journals.
- Stay current on cutting-edge scientific/technical developments in preclinical to clinical translation and apply them to advance portfolio programs.
- Ensure research/discovery work follows highest quality standards, ethical guidelines, and relevant regulatory, QC, and compliance guidelines.
Here is what you need (Minimum Requirements):
- BA/BS and 12 years, or MS and 9 years, or PhD and 4 years of relevant experience in biochemistry, cell biology and/or pharmacology. Industry and cardiometabolic experience are a plus.
- Experience supporting in vitro screening in a drug discovery environment with GPCR, enzyme, and other target protein classes; strong plate-based pharmacology background. Lab automation experience is a plus.
- Experience with Mechanism of Action (MoA) or molecular pharmacology, including hands-on traditional and novel screening methodologies; concepts related to GPCR/enzyme drug discovery, signaling and trafficking.
- Background on cell-based assay development and extensive mammalian cell culture experience.
- Scientific rigor; ability to critically review data and independently/creatively formulate and test hypotheses.
- Excellent communication and interpersonal skills; ability to work independently and in an interdisciplinary team.
- Strong scientific writing skills with publications in high-impact pharmacology journals and presentations at international conferences.
- Ability to mentor junior colleagues both technically and scientifically.
Physical/Mental Requirements:
- Ability to perform laboratory bench work and tissue culture; lifting, sitting, standing, walking, bending; mathematical calculations; complex data analysis.
Relocation support: Available.
Work Location Assignment: On Premise.
Compensation/benefits (if applicable):
- Annual base salary range: $106,000.00 to $176,600.00.
- Eligible for Global Performance Plan bonus target of 15.0% of base salary and share-based long term incentive program.
- 401(k) with Pfizer Matching Contributions; additional retirement savings contribution; paid vacation/holidays/personal days; paid caregiver/parental and medical leave; medical/prescription/dental/vision coverage.