Principal Scientist - In-vitro Display

Role Summary

Principal Scientist - In-vitro Display responsible for contributing to the discovery and development of biotherapeutics, focusing on in vitro display systems for novel antibody discovery, flow cytometry applications, and recombinant antibody expression and characterization. The role requires hands-on experience with flow cytometry, tissue culture, and knowledge of biochemistry and molecular biology related to protein engineering.

Responsibilities

• Discover, engineer, and optimize antibodies using in vitro display technologies to improve biological function, developability, and immunogenicity profiles
• Use biochemical and functional assays to evaluate antibody-antigen interactions including ELISA, cell binding and signaling assays, Octet or other SPR-based techniques
• Demonstrate strong expertise in molecular and cellular biology techniques including western blotting, PCR, cell culture, and site-directed mutagenesis
• Experience with antibody fusions, Fc-fusions, and conjugation to antibodies is highly desirable

Qualifications

• Basic: B.S./M.S. in a relevant field with at least 6+ years industry experience in molecular biology, biochemistry, or protein engineering
• Proven hands-on experience with fundamental biology techniques, including cell culture, viability assays, transfections, Western blot, affinity assays, image-based assays
• Strong experience in molecular biology including standard cloning techniques, sequence analysis, DNA and RNA extraction, ligation, PCR

Skills

• Experience with flow cytometry is highly desirable
• An understanding of antibody discovery, particularly with respect to in vitro display systems
• Excellent communication skills with a desire to be involved in collaborative, cross-functional work