Principal Scientist, Immunology
Biogen
June 30, 2026
On-site
San Francisco, CA
Clinical Research and Development
Key Responsibilities:
- Design and lead in vitro and in vivo studies to uncover mechanisms driving inflammatory and autoimmune diseases.
- Discover and validate novel drug targets, biomarkers, and pathways for immune-mediated disorders.
- Deliver high-quality data supporting lead optimization, biomarker development, and translational research.
- Analyze/interpret complex datasets with scientific rigor, reproducibility, and adherence to regulatory/safety standards; present internally and externally.
- Collaborate across disciplines (pharmacology, synthetic medicine, protein engineering, computational sciences) to advance target identification, drug discovery, and clinical development.
- Shape portfolio strategy by identifying scientific gaps and innovation opportunities.
- Partner with business development/corporate strategy to evaluate scientific merit of assets, collaborations, and licensing.
- Support due diligence (mechanistic evaluations, protocol reviews, external data assessment, IP analysis).
- Stay current on emerging immunology/inflammation research and technologies.
Qualifications:
- PhD in Immunology/Cellular & Molecular Biology or related field + 5+ years industry experience (MS 8+, BS 10+), preferably in inflammatory/autoimmune drug discovery and development.
- Expertise in immune cell biology (innate/adaptive), cell signaling, and immunological assay development.
- Hands-on experience with biochemical/cellular assay development, tissue culture, flow cytometry, and functional genomics.
- Experience with inflammation and/or autoimmunity disease models.
- Ability to manage multiple priorities; strong problem-solving; works independently and in teams.
- Analytical and communication skills to translate complex science into business-relevant insights.
Preferred Qualifications:
- 5+ years biotech/pharma drug discovery or translational research.
- Experience with small molecules, biologics, and/or cell-based therapeutics.
- Multiparametric flow cytometry (e.g., 15+ colors); multiomics experience.
- Due diligence/business development support experience (highly desirable).
Onsite/Location: South San Francisco, CA; frequent onsite presence; must be within commuting distance or able to self-relocate.
Compensation/Benefits (as stated): Base $142,000–$190,000; eligibility for short-/long-term incentives. Medical/Dental/Vision/Life, fitness reimbursement, disability, paid vacation + shutdown, holidays, sick time, paid maternity/parental leave, 401(k) match, stock purchase plan, tuition reimbursement up to $10,000/year, Employee Resource Groups participation.
- Design and lead in vitro and in vivo studies to uncover mechanisms driving inflammatory and autoimmune diseases.
- Discover and validate novel drug targets, biomarkers, and pathways for immune-mediated disorders.
- Deliver high-quality data supporting lead optimization, biomarker development, and translational research.
- Analyze/interpret complex datasets with scientific rigor, reproducibility, and adherence to regulatory/safety standards; present internally and externally.
- Collaborate across disciplines (pharmacology, synthetic medicine, protein engineering, computational sciences) to advance target identification, drug discovery, and clinical development.
- Shape portfolio strategy by identifying scientific gaps and innovation opportunities.
- Partner with business development/corporate strategy to evaluate scientific merit of assets, collaborations, and licensing.
- Support due diligence (mechanistic evaluations, protocol reviews, external data assessment, IP analysis).
- Stay current on emerging immunology/inflammation research and technologies.
Qualifications:
- PhD in Immunology/Cellular & Molecular Biology or related field + 5+ years industry experience (MS 8+, BS 10+), preferably in inflammatory/autoimmune drug discovery and development.
- Expertise in immune cell biology (innate/adaptive), cell signaling, and immunological assay development.
- Hands-on experience with biochemical/cellular assay development, tissue culture, flow cytometry, and functional genomics.
- Experience with inflammation and/or autoimmunity disease models.
- Ability to manage multiple priorities; strong problem-solving; works independently and in teams.
- Analytical and communication skills to translate complex science into business-relevant insights.
Preferred Qualifications:
- 5+ years biotech/pharma drug discovery or translational research.
- Experience with small molecules, biologics, and/or cell-based therapeutics.
- Multiparametric flow cytometry (e.g., 15+ colors); multiomics experience.
- Due diligence/business development support experience (highly desirable).
Onsite/Location: South San Francisco, CA; frequent onsite presence; must be within commuting distance or able to self-relocate.
Compensation/Benefits (as stated): Base $142,000–$190,000; eligibility for short-/long-term incentives. Medical/Dental/Vision/Life, fitness reimbursement, disability, paid vacation + shutdown, holidays, sick time, paid maternity/parental leave, 401(k) match, stock purchase plan, tuition reimbursement up to $10,000/year, Employee Resource Groups participation.