Principal Scientist II, Translational Biomarker Strategy Lead

Role: Lead development and execution of preclinical and translational biomarker strategies for Novartis DAx programs, serving as the biomarker representative on project teams. Responsibilities: define biomarker hypotheses, develop integrated plans encompassing assays and external collaborations, and generate translational evidence linking target biology to clinical decision-making. Collaborate across multiple disciplines, including Biology, Data Science, and Translational Medicine, to ensure biomarker strategies support target engagement, pharmacodynamics, and patient stratification from validation to early clinical stages. Requirements: PhD, MD, PharmD, or equivalent in biology, pharmacology, or related field; 7+ years in translational research, biomarker discovery, or drug development; proven experience developing biomarker strategies supporting clinical programs; strong understanding of target engagement, pharmacodynamics, and disease biomarkers. HighValue: focus on translational biomarkers supporting early clinical development, cross-functional leadership, external partnerships, and innovative technology integration. WorkSetup: not specified; likely hybrid or on-site based on location.