Principal Scientist II/Senior Principal Scientist, Modeling & Simulation (Dual Level Posting)

Role: Senior-level scientific modeler specializing in translational pharmacokinetics, pharmacodynamics, and systems pharmacology within biopharma. Responsibilities: develop and implement mechanistic models (PK/PD, QSP, PBPK/PD) to support drug discovery and clinical translation of oligonucleotide therapeutics, including antibody conjugates; guide decision-making from early dose design to lifecycle management; collaborate across teams to integrate modeling into preclinical and clinical studies; lead platform and strategy initiatives; promote modeling adoption internally and externally. Requirements: Ph.D. in relevant scientific fields (biology, bioengineering, pharmaceutical sciences) plus 3+ years industry experience (or Master’s + 5+ years); expert scripting and modeling skills (MATLAB, R, ODE modeling); proficiency in PK/PD, QSP, PBPK/PD, and pharmacometrics; experience with oligonucleotides or antibody-drug conjugates preferred; strong communication skills for multidisciplinary collaboration. HighValue: neuroscience and cardiovascular indications, oligonucleotide modalities, late preclinical to early clinical development phases, modeling for dose optimization and lifecycle management, hybrid work setup in Cambridge, MA, with ~12 days/month onsite.