Principal Scientist II - Pharmacology
Novartis
August 23, 2026
On-site
Cambridge, MA
Clinical Research and Development
Responsibilities:
- Design pre-clinical in vivo studies to explore novel hypotheses, screen candidate molecules, and establish proof-of-concept of new modalities
- Develop in vivo CDX, PDX, and syngeneic models to evaluate anti-tumor activity, PK/PD relationships, relevant biomarkers, and key translational questions
- Lead and manage associate-level scientists
- Collaborate with cross-functional project teams
- Critically analyze and present results in a multidisciplinary team environment
- Adhere to animal protocols and document data/methods in an electronic laboratory notebook
Qualifications:
- PhD with 5–8 years of research experience as a postdoc or in the pharmaceutical/biotech industry
- Deep knowledge of antibody drug conjugates (preferred)
- Extensive experience with CDX and PDX xenograft tumor models and/or syngeneic models
- Expertise in cell culture, PCR, ELISA, western blot, and flow cytometry
- Strong analytical, written/verbal communication, and organizational skills; proficiency with PowerPoint and data analysis tools such as Prism and Excel
- Design pre-clinical in vivo studies to explore novel hypotheses, screen candidate molecules, and establish proof-of-concept of new modalities
- Develop in vivo CDX, PDX, and syngeneic models to evaluate anti-tumor activity, PK/PD relationships, relevant biomarkers, and key translational questions
- Lead and manage associate-level scientists
- Collaborate with cross-functional project teams
- Critically analyze and present results in a multidisciplinary team environment
- Adhere to animal protocols and document data/methods in an electronic laboratory notebook
Qualifications:
- PhD with 5–8 years of research experience as a postdoc or in the pharmaceutical/biotech industry
- Deep knowledge of antibody drug conjugates (preferred)
- Extensive experience with CDX and PDX xenograft tumor models and/or syngeneic models
- Expertise in cell culture, PCR, ELISA, western blot, and flow cytometry
- Strong analytical, written/verbal communication, and organizational skills; proficiency with PowerPoint and data analysis tools such as Prism and Excel