Principal Scientist II
Novartis
June 24, 2026
On-site
Cambridge, MA
Clinical Research and Development
Key Responsibilities:
- Drive scientific activities supporting discovery and optimization of next-generation xDC and biologics platforms
- Design and evaluate new vectorization approaches for targeted delivery
- Develop payload strategies aligned with disease biology and therapeutic mechanism of action
- Explore differentiated conjugate formats, including multi-payload or combination-based approaches
- Collaborate with cross-functional teams across biology, chemistry, protein engineering, pharmacology, translational sciences, and CMC
- Design, execute, and interpret experiments to guide platform and program decisions
- Identify emerging scientific opportunities and translate them into actionable research strategies
- Communicate results via presentations, reports, and scientific discussions
- Support external collaborations and technology evaluation efforts as needed
- Maintain awareness of the competitive/scientific landscape in ADCs, biologics, and targeted therapeutics
Essential Requirements:
- Ph.D. in biology, biochemistry, molecular biology, pharmacology, immunology, chemical biology, bioengineering, or related discipline
- 3–5 years post-Ph.D. relevant experience (preferably industry)
- Experience with biologics, antibody-drug conjugates, targeted delivery platforms, protein therapeutics, or related modalities
- Strong understanding of disease biology, target selection, mechanism-of-action studies, and translational research principles
- Ability to design rigorous experiments, analyze complex data, and make data-driven recommendations
- Strong communication, collaboration, and problem-solving skills
- Ability to work effectively in a fast-paced, multidisciplinary research environment
Preferred Experience:
- Prior experience in ADC, xDC, or other targeted therapeutic platforms
- Experience evaluating novel targets/payload mechanisms or biology-driven therapeutic hypotheses
- Familiarity with in vitro and in vivo pharmacology workflows
- Experience with external partners (CROs, academic collaborators, vendors)
- Track record of scientific contributions (publications, patents, presentations, or program advancement)
- Drive scientific activities supporting discovery and optimization of next-generation xDC and biologics platforms
- Design and evaluate new vectorization approaches for targeted delivery
- Develop payload strategies aligned with disease biology and therapeutic mechanism of action
- Explore differentiated conjugate formats, including multi-payload or combination-based approaches
- Collaborate with cross-functional teams across biology, chemistry, protein engineering, pharmacology, translational sciences, and CMC
- Design, execute, and interpret experiments to guide platform and program decisions
- Identify emerging scientific opportunities and translate them into actionable research strategies
- Communicate results via presentations, reports, and scientific discussions
- Support external collaborations and technology evaluation efforts as needed
- Maintain awareness of the competitive/scientific landscape in ADCs, biologics, and targeted therapeutics
Essential Requirements:
- Ph.D. in biology, biochemistry, molecular biology, pharmacology, immunology, chemical biology, bioengineering, or related discipline
- 3–5 years post-Ph.D. relevant experience (preferably industry)
- Experience with biologics, antibody-drug conjugates, targeted delivery platforms, protein therapeutics, or related modalities
- Strong understanding of disease biology, target selection, mechanism-of-action studies, and translational research principles
- Ability to design rigorous experiments, analyze complex data, and make data-driven recommendations
- Strong communication, collaboration, and problem-solving skills
- Ability to work effectively in a fast-paced, multidisciplinary research environment
Preferred Experience:
- Prior experience in ADC, xDC, or other targeted therapeutic platforms
- Experience evaluating novel targets/payload mechanisms or biology-driven therapeutic hypotheses
- Familiarity with in vitro and in vivo pharmacology workflows
- Experience with external partners (CROs, academic collaborators, vendors)
- Track record of scientific contributions (publications, patents, presentations, or program advancement)