Principal Scientist I/II – Hematopoietic Stem Cell & RBC Biology
Novartis
August 24, 2026
On-site
Minnehaha County, SD
Clinical Research and Development
Major accountabilities:
- Apply expertise in sickle cell disease, hematopoietic stem cell biology, and RBC pathophysiology to support Global Health research initiatives.
- Design, execute, and interpret high-quality biological experiments that inform target discovery, validation, and early drug discovery.
- Translate biological insights into actionable hypotheses and therapeutic concepts in collaboration with multidisciplinary project teams.
- Take on increasing scientific leadership responsibilities, including mentoring junior scientists and contributing to team development (with future people-management growth opportunities).
- Foster a collaborative, inclusive, and high-performance culture aligned with Novartis Values & Behaviors.
- Contribute to project discussions, data reviews, and decision making in a matrixed Biomedical Research environment.
- Maintain awareness of external scientific advances and contribute to publications or scientific exchanges as appropriate.
- Ensure all work is conducted to the highest standards of scientific rigor, data integrity, safety, and compliance.
Minimum Requirements:
- PhD in Molecular Biology, Cell Biology, Immunology, Biochemistry, Microbiology, Virology, Biophysics, Pharmacology, or related biological science discipline.
- Deep expertise in sickle cell disease, red blood cell physiology, and/or hematopoietic stem cell biology, with strong understanding of hemoglobinopathies.
- Strong data interpretation, critical thinking, and scientific communication skills.
- Proven ability to independently design experiments, analyze data, and advance scientific questions (publications/patents/presentations/drug discovery contributions).
- Behaviors aligned with Inspired, Curious, Unbossed, and Integrity.
Preferred Qualifications:
- Early-career scientists (recent PhD/postdoc) transitioning into/expanding drug discovery experience.
- Experience in multidisciplinary and matrixed environments.
- Experience contributing to therapeutic programs from target identification/validation through lead generation and/or early development.
- Assay development expertise (in vitro, ex vivo, and/or in vivo systems).
- Prior high-dimensional flow cytometry experience (panel design, execution, data analysis) preferred.
Compensation/Benefits (if applicable):
- Expected salary range: $108,500–$208,500 USD annually; performance-based cash incentive; potential eligibility for annual equity awards.
- US-based eligible employees: comprehensive benefits package and time off.
Application instructions:
- For reasonable accommodation during the application process: email [email protected] or call +1(877)395-2339; include the job requisition number.
- Apply expertise in sickle cell disease, hematopoietic stem cell biology, and RBC pathophysiology to support Global Health research initiatives.
- Design, execute, and interpret high-quality biological experiments that inform target discovery, validation, and early drug discovery.
- Translate biological insights into actionable hypotheses and therapeutic concepts in collaboration with multidisciplinary project teams.
- Take on increasing scientific leadership responsibilities, including mentoring junior scientists and contributing to team development (with future people-management growth opportunities).
- Foster a collaborative, inclusive, and high-performance culture aligned with Novartis Values & Behaviors.
- Contribute to project discussions, data reviews, and decision making in a matrixed Biomedical Research environment.
- Maintain awareness of external scientific advances and contribute to publications or scientific exchanges as appropriate.
- Ensure all work is conducted to the highest standards of scientific rigor, data integrity, safety, and compliance.
Minimum Requirements:
- PhD in Molecular Biology, Cell Biology, Immunology, Biochemistry, Microbiology, Virology, Biophysics, Pharmacology, or related biological science discipline.
- Deep expertise in sickle cell disease, red blood cell physiology, and/or hematopoietic stem cell biology, with strong understanding of hemoglobinopathies.
- Strong data interpretation, critical thinking, and scientific communication skills.
- Proven ability to independently design experiments, analyze data, and advance scientific questions (publications/patents/presentations/drug discovery contributions).
- Behaviors aligned with Inspired, Curious, Unbossed, and Integrity.
Preferred Qualifications:
- Early-career scientists (recent PhD/postdoc) transitioning into/expanding drug discovery experience.
- Experience in multidisciplinary and matrixed environments.
- Experience contributing to therapeutic programs from target identification/validation through lead generation and/or early development.
- Assay development expertise (in vitro, ex vivo, and/or in vivo systems).
- Prior high-dimensional flow cytometry experience (panel design, execution, data analysis) preferred.
Compensation/Benefits (if applicable):
- Expected salary range: $108,500–$208,500 USD annually; performance-based cash incentive; potential eligibility for annual equity awards.
- US-based eligible employees: comprehensive benefits package and time off.
Application instructions:
- For reasonable accommodation during the application process: email [email protected] or call +1(877)395-2339; include the job requisition number.