Principal Scientist, High-Content Imaging

Role: Principal Scientist in High-Content Imaging within Johnson & Johnson's Innovative Medicine division, focusing on advancing therapeutic discovery in Immunology, Neuroscience, and Oncology. Responsibilities include developing, validating, and deploying complex high-content imaging assays across diverse cell models and tissues, establishing workflows, troubleshooting, and optimizing protocols. The role involves collaborating with internal teams, CROs, and external partners to generate high-quality data, support data analysis pipelines, and translate imaging readouts into biological insights. Qualifications: Ph.D. in Biochemistry, Systems Biology, or related field; minimum of 4 years industry experience with proven expertise in high-content imaging, assay development, and computational image analysis; excellent communication and collaborative skills. Preferred: experience with complex cell/tissue models, external collaborations, data integration, and programming in R/Python; familiarity with AI/ML approaches is a plus. High-value specifics include application across disease-relevant models in Immunology, Neuroscience, and Oncology, with a focus on drug discovery workflows. The position is based in Spring House, PA, with an emphasis on technical leadership and innovation in high-dimensional biological assays.