Principal Scientist, Drug Substance-Process Science/Immunology

Role: Principal Scientist in Cell Starting Material within Process Sciences, focusing on developing and characterizing cell therapy processes for Allogene's GMP manufacturing of off-the-shelf CAR T products. Responsibilities include designing high-impact cell starting material studies using QbD principles, evaluating innovative cell isolation technologies, and supporting process understanding for clinical and commercial scale-up. The role entails interpreting complex data, proposing process improvements, and collaborating across R&D, Analytical Sciences, MSAT, Quality, and Regulatory teams. Requirements: Ph.D. in Molecular & Cell Biology, Immunology, or related field with 7+ years (PhD), 10+ (MS), or 12+ (BS) years industry experience; expertise in immunology, cell-based assays, cell isolation, and bioprocessing; experience with cryopreservation and process optimization; strong data analysis skills and cross-functional leadership. Preferred: background in cell therapy manufacturing processes such as gene editing, viral transduction, and cell expansion. High-Value: focus on cell therapy, GMP manufacturing, process characterization, regulatory support, and cross-disciplinary collaboration. WorkSetup: Not specified, but likely within a GMP-enabled environment requiring scientific leadership and technical mentorship.