Principal Scientist, DMPK/ADME

Role: Principal Scientist leading DMPK/ADME strategies for complex molecular formats in metabolic disease drug discovery, establishing and expanding discovery platforms and bioanalytical capabilities. Responsibilities include designing and overseeing PK studies (internal and CRO), developing bioanalytical assays (LC-MS, immunoassays), interpreting data, supporting nonclinical study needs, and contributing to process improvements. Requirements: PhD in pharmaceutical sciences, biochemistry, chemistry or related, with 6+ years of DMPK/ADME experience in drug discovery involving complex modalities like antibodies, peptides, or conjugates. Skills in PK study design, data interpretation, bioanalysis, metabolite ID, and external vendor oversight are essential. Preferred qualifications include experience in regulatory documentation (IND/CTA support), automation-enabled workflows, and understanding of advanced drug modalities. High-Value: focus on antibody, peptide, and conjugate modalities, early-stage discovery (preclinical), with cross-functional R&D collaboration. Work setup: hybrid in Cambridge, MA; no travel specified.