Principal Scientist, DMPK

Role: Principal Scientist in Drug Metabolism and Pharmacokinetics (DMPK) focusing on oligonucleotide therapeutics and emerging modalities, leading strategies from discovery through clinical development. Responsibilities: design and execute DMPK studies to characterize ADME, PK/PD, and translational pharmacology; collaborate with research to optimize delivery and candidate selection; partner with cross-functional teams to integrate data for development decisions; apply modeling and simulation to support dose prediction and translational efforts; contribute to regulatory filings (CTA, IND). Qualifications: Ph.D. in pharmacokinetics, pharmaceutical sciences, or related field; 6+ years industry experience in pharma/biotech drug discovery and development; expertise in ADME, pharmacokinetics, PK/PD, and translational pharmacology; experience contributing to regulatory submissions and working in matrixed teams. Preferred: experience with oligonucleotide therapeutics, RNAi, ASO, modeling approaches (e.g., PBPK, population PK), regulatory interactions, and biomarkers. HighValue: focus on oligonucleotide therapeutics, early to clinical-stage development, regulatory filings (CTA/IND), quantitative pharmacology, cross-functional collaboration, in-office in Cambridge, MA.