Principal Scientist, Discovery DMPK Bioanalytical
GSK
Full-time
Remote friendly (Collegeville, PA)
United States
Clinical Research and Development
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Role Summary
Principal Scientist, Discovery DMPK Bioanalytical. Apply mass spectrometry skills to solve challenging bioanalytical problems and drive discovery programs, enabling patients’ access to therapies. Work within a fast-paced discovery laboratory environment across small molecules, oligonucleotides, biologics, and other modalities.
Responsibilities
- Utilize LC-MS approaches to support DMPK portfolio deliverables and bioanalytical work across modalities, including DMPK assays, exploratory biology experiments (e.g., PK-PD), and non-GLP toxicokinetic studies.
- Engage in broad scientific development within the team, expanding capabilities across sample preparation, separations, instrumentation, and data analysis to enable rapid design-make-test cycles.
Qualifications
- Ph.D. in Analytical Chemistry, Biochemistry, Pharmaceutical Sciences, or related field with 2+ years of postdoctoral/industry experience; or M.S. with 5+ years; or B.S. with 8+ years.
- Experience with DMPK principles and bioanalytical workflows; significant experience analyzing DMPK/related assays (in vitro, in vivo, toxicokinetic) using mass spectrometry.
- Experience in mass spectrometry-based analysis of small molecules in discovery settings.
- Experience in working with matrix teams to deliver complex studies by providing bioanalytical guidance into study protocols/designs and scheduling.
- Experience implementing new instrumentation, technology, and workflows to solve analytical problems.
Skills
- Strong laboratory bench skills and LC-MS techniques.
- Ability to troubleshoot instrumentation and workflows; capability to contribute to cross-functional study designs.
Education
- Ph.D. in Analytical Chemistry, Biochemistry, Pharmaceutical Sciences, or related, or equivalent with demonstrated experience; or B.S./M.S. with relevant industry background.
Additional Requirements
- Experience with Sciex mass spectrometers is a plus.
- Experience in discovery and GLP bioanalysis settings and delivering data on time with appropriate rigor.
- Previous bioanalysis experience with oligonucleotide therapeutics (siRNA, ASOs, or related modalities) is a plus.