Principal Scientist, Discovery DMPK Bioanalytical
GSK
Full-time
Remote friendly (Collegeville, PA)
United States
Clinical Research and Development
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Role Summary
Principal Scientist, Discovery DMPK Bioanalytical — You will apply mass spectrometry skills to solve challenging bioanalytical problems and support discovery programs across GSK’s portfolio, planning and building LC-MS capabilities for biologics in a fast-paced lab environment.
Responsibilities
- Support GSK’s portfolio deliverables using LC-MS approaches across modalities (large/small molecule, oligonucleotides, etc.) and provide leadership as a subject matter expert in large molecule LC-MS bioanalysis.
- Plan, develop, and execute large molecule LC-MS analyses required by the evolving portfolio; define trajectory of LC-MS approaches for biologics; collaborate cross-functionally to understand needs and deliver goals.
- Establish best practices for sample preparation, quantitation strategies, and data analysis to drive projects and build organizational expertise in biopharmaceutical bioanalysis.
Qualifications
- Required: Ph.D. in Analytical Chemistry, Biochemistry, Pharmaceutical Sciences, or related field with 2+ years postdoctoral/industry experience; or M.S. with 5+ years; or B.S. with 8+ years.
- Experience in mass spectrometry-based analysis of biopharmaceutics (e.g., antibodies, antibody-drug conjugates) and related components.
- Experience implementing new instrumentation, technology, and workflows to solve analytical problems.
- Experience with high-resolution mass spectrometry instrumentation and data analysis.
- Laboratory experience analyzing DMPK/related assays (in vitro, in vivo, toxicokinetic) using mass spectrometry.
Preferred Qualifications
- Proficient in using and troubleshooting Sciex mass spectrometers, including Time-of-Flight instruments.
- Experience with bioanalysis of oligonucleotide therapeutics (siRNA, ASOs, or related modalities).
- Prior involvement in matrix leadership, including cross-functional initiatives or guiding scientific strategy across multiple teams.
- Familiarity with regulatory expectations for large molecule bioanalysis.
Education
- Not specified beyond the required and preferred qualifications above.