Principal Scientist (Director), Translational Medicine - Cardiovascular
Merck
September 17, 2026
Full-time
Remote friendly (South San Francisco, CA)
Worldwide
Clinical Research and Development
Role: Principal Scientist (Clinical Director) leading early clinical development of novel cardiovascular therapeutics, from Preclinical Candidate approval through Phase 2. Responsibilities: craft and execute clinical strategies, develop biomarker and clinical platform validation plans, support target identification and validation, oversee Phase 1 studies, and provide pharmacology support for later-stage submissions. Collaborate broadly across Discovery Sciences, Clinical Research, and other functions. Requirements: MD or MD/PhD, proven record in clinical medicine or research, publication history, strong interpersonal and communication skills, and experience in translational medicine. Preferred: Clinical Board Certification or eligibility; subspecialty in Cardiology or related fields; prior translational or early clinical development experience; clinical management background. High-Value: Focus on cardiovascular disease, early clinical phase (Phases 1-2), biomarker strategy development, cross-functional collaboration, global clinical trial oversight, and hybrid work setup with 10% travel.