Principal Scientist (Director), Clinical Research, Immunology
Merck
September 15, 2026
Full-time
Remote friendly (San Francisco, CA)
Worldwide
Clinical Research and Development
Role: Clinical Director (Principal Scientist) leading late-stage immunology clinical research, focusing on investigational compounds in rheumatologic diseases. Responsibilities include developing clinical strategies, overseeing trial design, initiation, monitoring, and analysis; evaluating preclinical data for IND submissions; supporting business development opportunities; and collaborating with external experts and investigators. The role involves supervising clinical scientists, managing cross-functional teams in regulatory, manufacturing, and commercialization disciplines, and maintaining scientific expertise through ongoing research engagement. Requirements: MD, DO, MD/PhD, or DO/PhD with at least 5 years in clinical or development roles; experience in designing and executing phase 2/3 trials, particularly in rheumatology; strong interpersonal and teamwork skills; expertise in immunology and clinical development. Preferred: proven scholarly achievements and prior experience in rheumatology clinical trials. High-Value: focus on late-stage immunology, rheumatologic indications, with global external collaboration, traveling approximately 20-25%. Work setup: hybrid arrangement, with travel requirements; based in the U.S. with a salary range of $255,800β$402,700, plus benefits and bonuses.